Z
Zhijian Huang
Researcher at Guangzhou Institutes of Biomedicine and Health
Publications - 6
Citations - 192
Zhijian Huang is an academic researcher from Guangzhou Institutes of Biomedicine and Health. The author has contributed to research in topics: Reprogramming & Induced pluripotent stem cell. The author has an hindex of 5, co-authored 6 publications receiving 160 citations.
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Journal ArticleDOI
NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.
Qiang Zhuang,Wenjuan Li,Christina Benda,Zhijian Huang,Tanveer Ahmed,Ping Liu,Xiangpeng Guo,David P. Ibañez,Zhiwei Luo,Meng Zhang,Mazid Md. Abdul,Zhongzhou Yang,Jiayin Yang,Yinghua Huang,Hui Zhang,Dehao Huang,Dehao Huang,Jianguo Zhou,Xiaofen Zhong,Xihua Zhu,Xiuling Fu,Wenxia Fan,Yulin Liu,Yan Xu,Carl Ward,Muhammad Jadoon Khan,Shahzina Kanwal,Bushra Mirza,Micky D. Tortorella,Hung-Fat Tse,Hung-Fat Tse,Jiayu Chen,Baoming Qin,Xichen Bao,Shaorong Gao,Andrew P. Hutchins,Miguel A. Esteban +36 more
TL;DR: It is demonstrated that suppression of NCoR/SMRT enhances OSKM reprogramming efficiency, and that the barrier mechanism depends on the recruitment of HDAC3 to pluripotency loci by c-MYC.
Journal ArticleDOI
Transcriptional pause release is a rate-limiting step for somatic cell reprogramming.
Longqi Liu,Longqi Liu,Yan Xu,Yan Xu,Minghui He,Meng Zhang,Meng Zhang,Fenggong Cui,Leina Lu,Mingze Yao,Weihua Tian,Christina Benda,Christina Benda,Qiang Zhuang,Qiang Zhuang,Zhijian Huang,Wenjuan Li,Wenjuan Li,Xiangchun Li,Ping Zhao,Ping Zhao,Wenxia Fan,Zhiwei Luo,Zhiwei Luo,Yuan Li,Yasong Wu,Yasong Wu,Andrew P. Hutchins,Dongye Wang,Hung-Fat Tse,Hung-Fat Tse,Axel Schambach,Jonathan Frampton,Baoming Qin,Xichen Bao,Hongjie Yao,Biliang Zhang,Hao Sun,Duanqing Pei,Huating Wang,Jun Wang,Miguel A. Esteban +41 more
TL;DR: It is demonstrated that the reprogramming factor KLF4 helps recruit P-TEFb to pluripotency promoters and unveils an unanticipated role for KLF 4 in transcriptional pause release.
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Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells
Jiayin Yang,Yu Wang,Ting Zhou,Lai-Yung Wong,Xiao Yu Tian,Xueyu Hong,Wing-Hon Lai,Ka-Wing Au,Rui Wei,Liu Yuqing,Lai-Hung Cheng,Guichan Liang,Zhijian Huang,Wenxia Fan,Ping Zhao,Xiwei Wang,David P. Ibañez,Zhiwei Luo,Yingying Li,Xiaofen Zhong,Shuhan Chen,Dongye Wang,Li Li,Liangxue Lai,Baoming Qin,Xichen Bao,Andrew P. Hutchins,Chung-Wah Siu,Yu Huang,Miguel A. Esteban,Hung-Fat Tse +30 more
TL;DR: The iHep models recapitulate clinical observations of higher potency of PCSK9 antibodies compared with statins for reversing the consequences of FH, demonstrating the utility for preclinical testing of new therapies for FH patients.
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Solving the puzzle of Parkinson’s disease using induced pluripotent stem cells:
Ping Zhao,Zhiwei Luo,Weihua Tian,Jiayin Yang,David P. Ibañez,Zhijian Huang,Micky D. Tortorella,Miguel A. Esteban,Wenxia Fan +8 more
TL;DR: PD modeling with iPSCs is nowadays facilitated by the growing availability of high-efficiency neural-specific differentiation protocols and the possibility to correct or induce mutations as well as creating marker cell lines using designer nucleases.
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Class IIa Histone Deacetylases and Myocyte Enhancer Factor 2 Proteins Regulate the Mesenchymal-to-Epithelial Transition of Somatic Cell Reprogramming *
Qiang Zhuang,Xiaobing Qing,Xiaobing Qing,Yue Ying,Haitao Wu,Christina Benda,Jiao Lin,Zhijian Huang,Longqi Liu,Yan Xu,Xichen Bao,Baoming Qin,Duanqing Pei,Miguel A. Esteban +13 more
TL;DR: An unexpected role for a developmental axis in somatic cell reprogramming is highlighted and new insight is provided into how the MET is regulated in this context.