Rui Zhang

TL;DR: The concise fabrication of biocompatible BSO/GA-Fe(II)@liposome is presented as an effective adjuvant nanomedicine to promote clinically used conventional cancer chemotherapy and radiotherapy, by greatly amplifying the intratumoral oxidative stress.

TL;DR: A unique type of enzyme-encapsulated, photosensitizer-loaded hollow silica nanoparticles with rationally designed surface engineering as smart nanoreactors are designed, which show enhanced retention responding to the acidic tumor microenvironment and are able to further target mitochondria, the cellular organelle most sensitive to ROS.

TL;DR: PtCu3 nanocages are first reported as acting as a sonosensitizer with highly efficient ROS generation under ultrasound irradiation, and can act as horseradish peroxidase‐like nanozymes, catalyzing the decomposition of H2O2 into •OH under acidic conditions for CDT.

TL;DR: Based on this simple strategy, it is possible to achieve the dissociation of hypoxic‐responsive nanosystem to enhance the tumor penetration and therapeutic effect and combined photodynamic therapy and chemotherapy is realized to display superior antitumor efficacy in vivo.

TL;DR: This work synthesizes two-dimensional core-shell nanocomposites (Ti3C2@Au) via a seed-growth method starting from the titanium carbide nanosheets, a classical type of MXene nanostructure that could improve the tumor oxygenation, which significantly enhances the radiotherapy.