R
Ruizhong Wang
Researcher at University of Arizona
Publications - 22
Citations - 2122
Ruizhong Wang is an academic researcher from University of Arizona. The author has contributed to research in topics: Neuropathic pain & Nerve injury. The author has an hindex of 14, co-authored 17 publications receiving 1980 citations. Previous affiliations of Ruizhong Wang include National Institutes of Health.
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Journal ArticleDOI
Redistribution of NaV1.8 in Uninjured Axons Enables Neuropathic Pain
Michael S. Gold,Daniel Weinreich,Chang Sook Kim,Ruizhong Wang,James J. S. Treanor,Frank Porreca,Josephine Lai +6 more
TL;DR: Observations suggest that aberrant activity in uninjured C-fibers is a necessary component of pain associated with partial nerve injury and suggest that blocking NaV1.8 would be an effective treatment of neuropathic pain.
Journal ArticleDOI
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers.
Luis R. Gardell,Ruizhong Wang,Shannon E. Burgess,Michael H. Ossipov,Todd W. Vanderah,T. Philip Malan,Josephine Lai,Frank Porreca +7 more
TL;DR: Enhanced transmitter release may allow increased stimulus-evoked spinal excitation, which is likely to be critical for opioid-induced paradoxical pain.
Journal ArticleDOI
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain
Milena De Felice,Raul Sanoja,Ruizhong Wang,Louis P. Vera-Portocarrero,Janice Oyarzo,Tamara King,Michael H. Ossipov,Todd W. Vanderah,Josephine Lai,Gregory Dussor,Howard L. Fields,Theodore J. Price,Frank Porreca +12 more
TL;DR: A rat population with variable responses to nerve injury indicated that activation of descending inhibition with a spinal noradrenergic component prevents development of neuropathic pain, providing a mechanistic explanation for medications that engage descending inhibition or mimic its consequences.
Journal ArticleDOI
Triptan-induced latent sensitization: a possible basis for medication overuse headache.
Milena De Felice,Michael H. Ossipov,Ruizhong Wang,Josephine Lai,Juliana Geremias Chichorro,Ian D. Meng,David W. Dodick,Todd W. Vanderah,Gregory Dussor,Frank Porreca +9 more
TL;DR: Identification of the neural mechanisms underlying medication overuse headache resulting from triptans and their role in promoting substance abuse is identified.
Journal ArticleDOI
Multiple actions of systemic artemin in experimental neuropathy
Luis R. Gardell,Ruizhong Wang,Chris Ehrenfels,Michael H. Ossipov,Anthony Rossomando,Miller Stephan S,Carolyn Buckley,Amber K. Cai,Albert Tse,Susan F. Foley,Bang Jian Gong,Lee Walus,Paul Carmillo,Dane S. Worley,Carol Huang,Thomas Engber,Pepinsky R Blake,Richard L. Cate,Todd W. Vanderah,Josephine Lai,Dinah W. Y. Sah,Frank Porreca +21 more
TL;DR: It is shown that systemic, intermittent administration of artemin produces dose- and time-related reversal of nerve injury–induced pain behavior, together with partial to complete normalization of multiple morphological and neurochemical features of the injury state.