R
Rulang Jiang
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 90
Citations - 7738
Rulang Jiang is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Mesenchyme & Gene. The author has an hindex of 42, co-authored 83 publications receiving 6977 citations. Previous affiliations of Rulang Jiang include University of Cincinnati Academic Health Center & University of Rochester Medical Center.
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The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition.
TL;DR: In the case of mouse embryos deficient for the Snail (Sna) gene, a mesoderm layer forms and mesodermal marker genes are induced, and cells lining these lacunae retain epithelial characteristics.
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Notch signalling pathway mediates hair cell development in mammalian cochlea.
Pamela J. Lanford,Yu Lan,Rulang Jiang,Claire E. Lindsell,Gerry Weinmaster,Thomas Gridley,Matthew W. Kelley +6 more
TL;DR: In this article, it was shown that genes encoding the receptor protein Notch1 and its ligand, Jagged 2, are expressed in alternating cell types in the developing sensory epithelium.
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Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
Rulang Jiang,Yu Lan,H D Chapman,Carrie J. Shawber,Christine R. Norton,David V. Serreze,Gerry Weinmaster,Thomas Gridley +7 more
TL;DR: It is demonstrated that Notch signaling mediated by Jag2 plays an essential role during limb, craniofacial, and thymic development in mice, as well as in the foot plates of the mutant homozygotes.
Journal ArticleDOI
Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development
Jeffrey O. Bush,Rulang Jiang +1 more
TL;DR: Major advances in the understanding of the morphogenetic and molecular mechanisms controlling palatal shelf growth, elevation, adhesion and fusion, and palatal bone formation are reviewed.
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Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.
Brent McCright,Xiang Gao,Liya Shen,Julie Lozier,Yu Lan,Maureen Maguire,Doris Herzlinger,Gerry Weinmaster,Rulang Jiang,Thomas Gridley +9 more
TL;DR: The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism and the co-localization and genetic interaction of Jag1 and Notch2 imply that this ligand and receptor physically interact.