M
Maureen Maguire
Researcher at Schering-Plough
Publications - 15
Citations - 4633
Maureen Maguire is an academic researcher from Schering-Plough. The author has contributed to research in topics: Receptor & Cholesterol absorption inhibitor. The author has an hindex of 13, co-authored 14 publications receiving 4308 citations.
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Journal ArticleDOI
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.
Scott W. Altmann,Harry R. Davis,Li-ji Zhu,Xiaorui Yao,Lizbeth M. Hoos,Glen Tetzloff,Sai Prasad N. Iyer,Maureen Maguire,Andrei Golovko,Ming Zeng,Luquan Wang,Nicholas J. Murgolo,Michael P. Graziano +12 more
TL;DR: It is shown that Niemann-Pick C1Like 1(NPC1L1) protein plays a critical role in the absorption of intestinal cholesterol, and resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption.
Journal ArticleDOI
Notch signaling is essential for vascular morphogenesis in mice.
Luke T. Krebs,Yingzi Xue,Christine R. Norton,John R. Shutter,Maureen Maguire,John P. Sundberg,Daniel Gallahan,Violaine Closson,Jan Kitajewski,Robert Callahan,Gilbert H. Smith,Kevin Lee Stark,Thomas Gridley +12 more
TL;DR: An essential role for the Notch signaling pathway in regulating embryonic vascular morphogenesis and remodeling is revealed and it is indicated that whereas the NotCh4 gene is not essential during embryonic development, the notch4 and Notch1 genes have partially overlapping roles during embryogenesis in mice.
Journal ArticleDOI
Niemann-Pick C1 Like 1 (NPC1L1) Is the Intestinal Phytosterol and Cholesterol Transporter and a Key Modulator of Whole-body Cholesterol Homeostasis
Harry R. Davis,Li-ji Zhu,Lizbeth M. Hoos,Glen Tetzloff,Maureen Maguire,Jianjun Liu,Xiaorui Yao,Sai Prasad N Iyer,My-Hanh Lam,Erik G. Lund,Patricia A. Detmers,Michael P. Graziano,Scott W. Altmann +12 more
TL;DR: NPC1L1 is required for intestinal uptake of both cholesterol and phytosterols and plays a major role in cholesterol homeostasis and may be a useful drug target for the treatment of hypercholesterolemia and sitosterolemia.
Journal ArticleDOI
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.
Brent McCright,Xiang Gao,Liya Shen,Julie Lozier,Yu Lan,Maureen Maguire,Doris Herzlinger,Gerry Weinmaster,Rulang Jiang,Thomas Gridley +9 more
TL;DR: The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism and the co-localization and genetic interaction of Jag1 and Notch2 imply that this ligand and receptor physically interact.
Journal ArticleDOI
Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E2 and cytokines.
Mary Ann Cox,James V. Jackson,Michaela C. Stanton,Alberto Rojas-Triana,Loretta A. Bober,Maureen Laverty,Xiaoxin Yang,Feng Zhu,Jianjun Liu,Suke Wang,Frederick J. Monsma,Galya Vassileva,Maureen Maguire,Eric A. Gustafson,Marvin L. Bayne,Chuan-Chu Chou,Daniel Lundell,Chung-Her Jenh +17 more
TL;DR: It is shown that SCFAs can induce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysaccharide (LPS), and it is demonstrated that P GE2 production induced by SCFA was inhibited by pertussis toxin, suggesting the involvement of a receptor-mediated mechanism.