R
Ruli Zhang
Researcher at National Institutes of Health
Publications - 14
Citations - 644
Ruli Zhang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Pre-Bötzinger complex & Inhibitory postsynaptic potential. The author has an hindex of 8, co-authored 12 publications receiving 532 citations.
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Journal ArticleDOI
Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P
Krzysztof Ptak,Tadashi Yamanishi,Jason Aungst,Lorin S. Milescu,Ruli Zhang,George B. Richerson,Jeffrey C. Smith +6 more
TL;DR: It is concluded that raphé 5-HT neurons excite key circuit components required for generation of respiratory motor output in neonatal and juvenile rats, and can transform the electrophysiological phenotype of some pre-BötC neurons to intrinsic bursters, providing 5- HT with an additional role in promoting rhythm generation.
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Structural-Functional Properties of Identified Excitatory and Inhibitory Interneurons within Pre-Bötzinger Complex Respiratory Microcircuits
Hidehiko Koizumi,Naohiro Koshiya,Justine X. Chia,Fang Cao,Joseph Nugent,Ruli Zhang,Jeffrey C. Smith +6 more
TL;DR: The results are consistent with the concepts of a compartmental circuit organization, a bilaterally coupled excitatory rhythmogenic kernel, and a role of pre-BötC inhibitory neurons in shaping inspiratory pattern as well as coordinating inspiratory and expiratory activity.
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Perturbations of Respiratory Rhythm and Pattern by Disrupting Synaptic Inhibition within Pre-Bötzinger and Bötzinger Complexes.
Vitaliy Marchenko,Hidehiko Koizumi,Bryan Mosher,Naohiro Koshiya,Mohammad F. Tariq,Tatiana Bezdudnaya,Ruli Zhang,Yaroslav I. Molkov,Ilya A. Rybak,Jeffrey C. Smith +9 more
TL;DR: Investigating the roles of synaptic inhibition and the BötC in anesthetized adult rats in vivo and in perfused in situ brainstem–spinal cord preparations from juvenile rats concluded that inhibitory circuit interactions within and between the pre-B ÖtC and BöTC critically regulate rhythmogenesis and are required for normal respiratory motor pattern generation.
Journal ArticleDOI
TASK Channels Contribute to the K+-Dominated Leak Current Regulating Respiratory Rhythm Generation In Vitro
Hidehiko Koizumi,Stanley E. Smerin,Tadashi Yamanishi,Bindiya R. Moorjani,Ruli Zhang,Jeffrey C. Smith +5 more
TL;DR: It is concluded that TASK-like channels play a major functional role in chemosensory modulation of respiratory rhythm generation in the pre-Bötzinger complex in vitro.
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Voltage-Dependent Rhythmogenic Property of Respiratory Pre-Bötzinger Complex Glutamatergic, Dbx1-Derived, and Somatostatin-Expressing Neuron Populations Revealed by Graded Optogenetic Inhibition.
TL;DR: It is inferred that enough of the rhythmogenic pre-BötC glutamatergic neurons also have the Dbx1 and Sst expression phenotypes, and thus all three phenotypes share the same voltage-dependent frequency control property.