K
Krzysztof Ptak
Researcher at Northwestern University
Publications - 20
Citations - 907
Krzysztof Ptak is an academic researcher from Northwestern University. The author has contributed to research in topics: Bursting & Pre-Bötzinger complex. The author has an hindex of 12, co-authored 20 publications receiving 854 citations. Previous affiliations of Krzysztof Ptak include National Institutes of Health & University of California, Los Angeles.
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Journal ArticleDOI
Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P
Krzysztof Ptak,Tadashi Yamanishi,Jason Aungst,Lorin S. Milescu,Ruli Zhang,George B. Richerson,Jeffrey C. Smith +6 more
TL;DR: It is concluded that raphé 5-HT neurons excite key circuit components required for generation of respiratory motor output in neonatal and juvenile rats, and can transform the electrophysiological phenotype of some pre-BötC neurons to intrinsic bursters, providing 5- HT with an additional role in promoting rhythm generation.
Journal ArticleDOI
Resurgent Na currents in four classes of neurons of the cerebellum.
Fatemeh S. Afshari,Krzysztof Ptak,Zayd M. Khaliq,Tina M. Grieco,N. Traverse Slater,Donald R. McCrimmon,Indira M. Raman +6 more
TL;DR: Results indicate that resurgent current is typical of many cerebellar neurons and suggest that rapid open-channel block and unblock may be a widespread mechanism for restoration of Na channel availability in rapidly firing neurons.
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Sodium Currents in Medullary Neurons Isolated from the Pre-Bötzinger Complex Region
Krzysztof Ptak,Greer G. Zummo,George F. Alheid,Tatiana Tkatch,D. James Surmeier,Donald R. McCrimmon +5 more
TL;DR: Findings imply that INaP and INaT arise from the same channels and that a simple modification of the Hodgkin-Huxley model can satisfactorily account for both currents.
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Real-Time Kinetic Modeling of Voltage-Gated Ion Channels Using Dynamic Clamp
TL;DR: A new technique for modeling the kinetics of voltage-gated ion channels in a functional context, in neurons or other excitable cells, on the basis of a computational model that explains both the observed cellular dynamics and the biophysical properties of the channel.
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Nanotechnology-Based Cancer Therapeutics—Promise and Challenge—Lessons Learned Through the NCI Alliance for Nanotechnology in Cancer
TL;DR: Current developments in nanotechnology-based drug delivery are summarized and path forward in this field is discussed in context of research and development occurring within the NCI Alliance for Nanotechnology in Cancer program.