Runyu Yang

TL;DR: Limonin mitigated APAP-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1, and demonstrated that limonin had therapeutic promise in AP AP-induced liver injury.

TL;DR: It is demonstrated that Glaucocalyxin A inhibited EMT and TGF-β1-induced EMT by inhibiting TGF -β1/Smad2/3 signaling pathway in osteosarcoma.

TL;DR: In this paper, the authors investigated the protection of limonin, an antioxidant compound from citrus fruit, against LPS-induced liver toxicity and elucidate the potential mechanisms, and they found that limonins elevated cell viability and reduced LDH release in LPS treated HepG2 cells.

TL;DR: Limonin relieved the risk and severity of DSS-induced chronic colitis in mice through various aspects including increasing body weight and colon length, decreasing the mortality rate, inhibiting MPO activity and improving colon pathology, and provides the possibility for limonin as an effective drug for chroniccolitis of IBD in the future.

TL;DR: In this article , the role of RIPK2 in prognosis and immunotherapy response is yet to be elucidated in human pan-cancer by investigating the expression, gene alteration landscape and prognostic value of RIPk2 in 33 cancers through various databases including Ualcan, cBioportal and Gene Expression Profiling Interactive Analysis 2.