Xiubo Jiang

TL;DR: Oridonin exerted a dramatic pro-apoptotic effect by activating PPAR-γ and inhibiting Nrf2 pathway in vitro and in vivo, and may be a promising and effective agent for human osteosarcoma in the future clinical applications.

TL;DR: Limonin mitigated APAP-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1, and demonstrated that limonin had therapeutic promise in AP AP-induced liver injury.

TL;DR: It is demonstrated that Glaucocalyxin A inhibited EMT and TGF-β1-induced EMT by inhibiting TGF -β1/Smad2/3 signaling pathway in osteosarcoma.

TL;DR: It is suggested that Glaucocalyxin A induced apoptosis in osteosarcoma by inhibiting nuclear translocation of GLI1 via regulating PI3K/Akt signaling pathway, which might be a potential candidate for human osteosARcoma in the future.

TL;DR: Investigating the underlying mechanism of oridonin on EMT and metastasis of osteosarcoma found that oridon in inhibited migration and invasion of MG-63 and 143B cells and increased the protein expression of E-cadherin and decreased that of N- cadher in and Vimentin.