R
Russell C. Cattley
Researcher at Research Triangle Park
Publications - 65
Citations - 5589
Russell C. Cattley is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Peroxisome Proliferation & Phthalate. The author has an hindex of 34, co-authored 62 publications receiving 5444 citations. Previous affiliations of Russell C. Cattley include North Carolina State University College of Veterinary Medicine.
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Journal ArticleDOI
Male Reproductive Tract Malformations in Rats Following Gestational and Lactational Exposure to Di(n-butyl) Phthalate: An Antiandrogenic Mechanism?
TL;DR: DBP specifically impaired the androgen-dependent development of the male reproductive tract, suggesting that DBP is not estrogenic but antiandrogenic in the rat at these high dose levels.
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Dose-Dependent Alterations in Androgen-Regulated Male Reproductive Development in Rats Exposed to Di(n-butyl) Phthalate during Late Gestation
TL;DR: For this 10-day prenatal (embryonic and fetal) exposure to DBP, the NOAEL and LOAEL (lowest-observed-adverse-effect level) were 50 and 100 mg/kg/day, respectively, this is currently the lowest NoAEL described for the toxicity of DBP.
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Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide.
TL;DR: DBP is an example of an environmental antiandrogen that disrupts androgen-regulated male sexual differentiation without interacting directly with the androgen receptor (AR) in vitro, as does flutamide.
Journal Article
Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.
TL;DR: A strong correlation was observed between the relative hepatocarcinogenicity of DEHP and Wy-14,643 and the ability to induce a persistent increase in replicative DNA synthesis, emphasizing the possible importance of cell replication in the mechanism of PP-induced hepatOCarcinogenesis.
Journal ArticleDOI
A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines
John Doull,Russell C. Cattley,Cliff Elcombe,Brian G. Lake,James A. Swenberg,Chris F. Wilkinson,Gary M. Williams,Marcia van Gemert +7 more
TL;DR: The hepatocarcinogenic response of rodents to DEHP is not relevant to human cancer risk at any anticipated exposure level, and DEHP should be classified an unlikely human carcinogen with a margin of exposure (MOE) approach to risk assessment.