R
Rutger Meinsma
Researcher at University of Amsterdam
Publications - 58
Citations - 2334
Rutger Meinsma is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Dihydropyrimidine dehydrogenase & Dihydropyrimidine dehydrogenase deficiency. The author has an hindex of 24, co-authored 56 publications receiving 2134 citations. Previous affiliations of Rutger Meinsma include Boston Children's Hospital & Academic Medical Center.
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Journal Article
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.
A. B. P. Van Kuilenburg,E W Muller,Janet Haasjes,Rutger Meinsma,Lida Zoetekouw,Hans R. Waterham,Frank Baas,Dick J. Richel,A. H. van Gennip +8 more
TL;DR: In this paper, the authors demonstrated that a lethal toxicity after a treatment with 5-fluorouracil (5FU) was attributable to a complete deficiency of DPD, showing that patients with a partial deficiency of this enzyme are at risk from developing a severe 5FU-associated toxicity.
Journal ArticleDOI
Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency.
A. B. P. Van Kuilenburg,Peter Vreken,N. G. G. M. Abeling,Henk D. Bakker,Rutger Meinsma,H. van Lenthe,R.A. de Abreu,Jan A.M. Smeitink,Hülya Kayserili,Memnune Yüksel Apak,Ernst Christensen,I. Holopainen,Kari Pulkki,Daria Riva,G. Botteon,Elisabeth Holme,Mar Tulinius,W. J. Kleijer,Frits A. Beemer,M. Duran,K. E. Niezen-Koning,Gerrit Smit,Cornelis Jakobs,L. M. E. Smit,A. H. van Gennip +24 more
TL;DR: Analysis of the prevalence of the various mutations among DPD patients has shown that the G→A point mutation in the invariant splice donor site is by far the most common (52%), whereas the other six mutations are less frequently observed.
Journal ArticleDOI
Increased risk of grade IV neutropenia after administration of 5‐fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: High prevalence of the IVS14+1g>a mutation
TL;DR: Screening of patients at risk before administration of 5‐FU‐related toxicities in patients with low DPD activity and the apparently high prevalence of the IVS14+1G>A mutation is warranted.
Journal ArticleDOI
High prevalence of the IVS14+1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity
TL;DR: In this article, the authors evaluated the DPD activity and the prevalence of the common splice site mutation IVS14 + 1G>A in tumour patients suffering from severe grade 3-4 toxicity after the administration of 5FU.
Journal Article
Dihydropyrimidinase Deficiency and Severe 5-Fluorouracil Toxicity
André B.P. van Kuilenburg,Rutger Meinsma,Bernard A Zonnenberg,Lida Zoetekouw,Frank Baas,Koichi Matsuda,Nanaya Tamaki,Albert H. van Gennip +7 more
TL;DR: It is demonstrated for the first time that in one patient the severe toxicity, after a treatment with 5FU, was attributable to a partial deficiency of DHP.