R
Ruth A. Crowe
Researcher at University of North Carolina at Chapel Hill
Publications - 2
Citations - 1393
Ruth A. Crowe is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Mitochondrial permeability transition pore & Apoptosis. The author has an hindex of 1, co-authored 2 publications receiving 1359 citations.
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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
John J. Lemasters,Anna Liisa Nieminen,Ting Qian,Lawrence C. Trost,Lawrence C. Trost,Steven P. Elmore,Yoshiya Nishimura,Ruth A. Crowe,Wayne E. Cascio,Cynthia A. Bradham,David A. Brenner,Brian Herman +11 more
TL;DR: In vitro findings suggest that the MPT is the pathophysiological mechanism underlying Reye's syndrome in vivo, and a model is proposed in which onset of theMPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death.