T
Ting Qian
Researcher at University of North Carolina at Chapel Hill
Publications - 37
Citations - 6689
Ting Qian is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Mitochondrial permeability transition pore & Apoptosis. The author has an hindex of 28, co-authored 37 publications receiving 6483 citations.
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Journal ArticleDOI
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
John J. Lemasters,Anna Liisa Nieminen,Ting Qian,Lawrence C. Trost,Lawrence C. Trost,Steven P. Elmore,Yoshiya Nishimura,Ruth A. Crowe,Wayne E. Cascio,Cynthia A. Bradham,David A. Brenner,Brian Herman +11 more
TL;DR: In vitro findings suggest that the MPT is the pathophysiological mechanism underlying Reye's syndrome in vivo, and a model is proposed in which onset of theMPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death.
Journal ArticleDOI
The mitochondrial permeability transition initiates autophagy in rat hepatocytes
TL;DR: The MPT initiates mitochondrial depolarization after autophagic stimulation and the subsequent sequestration of mitochondria into autophagosomes, and this depolarized mitochondria moved into acidic vacuoles labeled by LysoTracker Red.
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NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis
Ramon Bataller,Robert F. Schwabe,Youkyung Hwang Choi,Liu Yang,Yong-Han Paik,Jeffrey N. Lindquist,Ting Qian,Robert Schoonhoven,Curt H. Hagedorn,John J. Lemasters,David A. Brenner,David A. Brenner +11 more
TL;DR: NADPH oxidase mediates the actions of Ang II on HSCs and plays a critical role in liver fibrogenesis, as assessed by microarray analysis.
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The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release
Cynthia A. Bradham,Ting Qian,Konrad L. Streetz,Christian Trautwein,David A. Brenner,John J. Lemasters +5 more
TL;DR: The MPT is an essential component in the signaling pathway for TNFα-induced apoptosis in hepatocytes which is required for both cytochrome c release and cell death and functions downstream of FADD and crmA but upstream of caspase 3.
Journal ArticleDOI
Mitochondrial Dysfunction in the Pathogenesis of Necrotic and Apoptotic Cell Death
John J. Lemasters,Ting Qian,Cynthia A. Bradham,David A. Brenner,Wayne E. Cascio,Lawrence C. Trost,Yoshiya Nishimura,Anna Liisa Nieminen,Brian Herman +8 more
TL;DR: Cyclosporin A blocks this mitochondrial permeability transition (MPT) and prevents necrotic cell death from oxidative stress, Ca2+ ionophore toxicity, eye-related drug toxicity, pH-dependent ischemia/reperfusion injury, and other models of cell injury.