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Wayne E. Cascio
Researcher at University of North Carolina at Chapel Hill
Publications - 96
Citations - 9802
Wayne E. Cascio is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Heart rate & Population. The author has an hindex of 39, co-authored 91 publications receiving 9208 citations. Previous affiliations of Wayne E. Cascio include East Carolina University & Rex Hospital.
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Journal ArticleDOI
Air Pollution and Cardiovascular Disease A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association
Robert D. Brook,Barry A. Franklin,Wayne E. Cascio,Yuling Hong,George Howard,Michael Lipsett,Russell V. Luepker,Murray A. Mittleman,Jonathan M. Samet,Sidney C. Smith,Ira B. Tager +10 more
TL;DR: The purpose of this statement is to provide healthcare professionals and regulatory agencies with a comprehensive review of the literature on air pollution and cardiovascular disease and practical recommendations for healthcare providers and their patients are outlined.
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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
John J. Lemasters,Anna Liisa Nieminen,Ting Qian,Lawrence C. Trost,Lawrence C. Trost,Steven P. Elmore,Yoshiya Nishimura,Ruth A. Crowe,Wayne E. Cascio,Cynthia A. Bradham,David A. Brenner,Brian Herman +11 more
TL;DR: In vitro findings suggest that the MPT is the pathophysiological mechanism underlying Reye's syndrome in vivo, and a model is proposed in which onset of theMPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death.
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Particulate Matter Exposure in Cars Is Associated with Cardiovascular Effects in Healthy Young Men
Michael Riediker,Wayne E. Cascio,Thomas R. Griggs,Margaret C. Herbst,Philip A. Bromberg,Lucas M. Neas,Ronald Williams,Robert B. Devlin +7 more
TL;DR: The observations in young, healthy, nonsmoking, male North Carolina Highway Patrol troopers suggest that in-vehicle exposure to PM(2.5) may cause pathophysiologic changes that involve inflammation, coagulation, and cardiac rhythm.
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Mitochondrial Dysfunction in the Pathogenesis of Necrotic and Apoptotic Cell Death
John J. Lemasters,Ting Qian,Cynthia A. Bradham,David A. Brenner,Wayne E. Cascio,Lawrence C. Trost,Yoshiya Nishimura,Anna Liisa Nieminen,Brian Herman +8 more
TL;DR: Cyclosporin A blocks this mitochondrial permeability transition (MPT) and prevents necrotic cell death from oxidative stress, Ca2+ ionophore toxicity, eye-related drug toxicity, pH-dependent ischemia/reperfusion injury, and other models of cell injury.
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Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy.
John J. Lemasters,Ting Qian,Lihua He,Jae-Sung Kim,Steven P. Elmore,Wayne E. Cascio,David A. Brenner +6 more
TL;DR: A new term, necrapoptosis, describes such death processes that begin with a common stress or death signal, progress by shared pathways, but culminate in either cell lysis (necrosis) or programmed cellular resorption (apoptosis), depending on modifying factors such as ATP.