Showing papers by "Ruth Duncan published in 2000"
TL;DR: Dendrimers are highly branched macromolecules of low polydispersity that provide many exciting opportunities for design of novel drug-carriers, gene delivery systems and imaging agents but it is clear that dendrimer structure must also be carefully tailored to avoid rapid hepatic uptake if targeting elsewhere (e.g. tumour targeting).
1,170 citations
TL;DR: As the anionic PAMAM dendrimers displayed serosal transfer rates that were faster than observed for other syntheticand natural macromolecules (including tomato lectin) studied in the evertedsac system, these interesting nanoscale structures may have potential for further development as oral drug delivery systems.
Abstract: Purpose. To investigate systematically the effect ofpolyamidoamine (PAMAM) dendrimer size, charge, and concentration on uptakeand transport across the adult rat intestine in vitro using theeverted rat intestinal sac system.
224 citations
TL;DR: In this article, five poly(amido-amine)s (PAAs) carrying two teramino groups and one carboxyl group per repeating unit were prepared by hydrogen-transfer polyaddition of 2-methylpiperazine (ISA 23), 1,2-bis(N-methylamino)ethane (DMEDA-BAC), 1 2 -bis(acrylamido)acetic acid (BAC).
Abstract: Five poly(amido-amine)s (PAAs) carrying two ter-amino groups and one carboxyl group per repeating unit were prepared by hydrogen-transfer polyaddition of 2-methylpiperazine (ISA 23), 1,2-bis(N-methylamino)ethane (DMEDA-BAC), 1,2-bis(N-ethylamino)ethane (DEEDA-BAC, 1,3-bis(N-methylamino)propane (DMEPDA-BAC), or 1,6-bis(N-methylamino)hexane (DMEXA-BAC), in each case to 2,2-bis(acrylamido)acetic acid (BAC). The resultant PAAs had an Mn in the range 7 985−24 980 g/mole and an Mw in the range 11 420−42 710 g/mole. Considerable differences were observed in the basicity of the amino groups present (log K°1 = 7.5−9.5; log K°2 = 3.2−8.4), whereas the log K°3 value (2−3) of the carboxyl groups was consistent with that of a fairly strong acid. DEEDA-BAC, DMEDA-BAC, and ISA 23 were nontoxic (IC50 > 5 mg/mL). Those PAAs with the highest log K°2 values were more cytotoxic (IC50 = 3.55 mg/mL for DMEPDA-BAC, and IC50 = 0.23 m/mL for DMEXA-BAC). All the PAAs displayed pH-dependent haemolysis (most lytic at pH 5.5), consis...
122 citations
43 citations
Patent•
19 Jun 2000
TL;DR: In this article, a polymer drug conjugate for the treatment of cancer comprising a succinoylated dextrin was proposed. But, the authors did not specify how to obtain the stability of the conjugates.
Abstract: The invention relates to a polymer drug conjugate for the treatment of cancer comprising a succinoylated dextrin wherein said succinoylation enhances the in vivo stability of said conjugate.
23 citations