Ruth Lupu

TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.

TL;DR: The results indicate that when breast cells are spatially organized as a result of contact with basement membrane, the signaling pathways become coupled and bidirectional and explain why breast cells fail to differentiate in monolayer cultures in which these events are mostly uncoupled.

TL;DR: Evidence of an active role of FAS in cancer evolution is provided by specifically regulating oncogenic proteins closely related to malignant transformation, strongly suggesting that HER2 oncogene may act as the key molecular sensor of energy imbalance after the perturbation of tumor-associated FAS hyperactivity in cancer cells.

TL;DR: Evidence described here suggests that gp30 is a ligand for p185erbB2, a 185-kilodalton transmembrane protein whose sequence is similar to the epidermal growth factor receptor (EGFR).

TL;DR: These findings demonstrate that OA, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu overexpression, which, in turn, interacts synergistically with anti-Her-2-neu immunotherapy by promoting apoptotic cell death of breast cancer cells with Her- 2/neU oncogene amplification.