R
Ruth S. MacDonald
Researcher at Iowa State University
Publications - 67
Citations - 3416
Ruth S. MacDonald is an academic researcher from Iowa State University. The author has contributed to research in topics: Genistein & Phytoestrogens. The author has an hindex of 29, co-authored 67 publications receiving 3117 citations. Previous affiliations of Ruth S. MacDonald include City University of New York & University of Minnesota.
Papers
More filters
Journal ArticleDOI
The Role of Zinc in Growth and Cell Proliferation
TL;DR: Evidence suggests that reduced zinc availability affects membrane signaling systems and intracellular second messengers that coordinate cell proliferation in response to IGF-I, and may directly regulate DNA synthesis through these systems.
Journal ArticleDOI
Neuroprotective mechanisms of curcumin against cerebral ischemia‐induced neuronal apoptosis and behavioral deficits
Qun Wang,Albert Y. Sun,Agnes Simonyi,Michael D. Jensen,Phullara B. Shelat,George E. Rottinghaus,Ruth S. MacDonald,Dennis K. Miller,Dennis E. Lubahn,Gary A. Weisman,Grace Y. Sun +10 more
TL;DR: The neuroprotective effect of curcumin is attributed against I/R‐induced neuronal damage to its antioxidant capacity in reducing oxidative stress and the signaling cascade leading to apoptotic cell death.
Journal ArticleDOI
Processed foods: contributions to nutrition
Connie M. Weaver,Johanna T. Dwyer,Victor L. Fulgoni,Janet C. King,Gilbert A. Leveille,Ruth S. MacDonald,Jose M. Ordovas,David Schnakenberg +7 more
TL;DR: Analyses of the NHANES 2003-2008 show that processed foods provide both nutrients to encourage and constituents to limit as specified in the 2010 Dietary Guidelines for Americans.
Journal ArticleDOI
Genistein Alters Methylation Patterns in Mice
J. Kevin Day,Andrew Bauer,Charles Desbordes,Yi Zhuang,Byung-Eun Kim,Leslie G. Newton,Vedika Nehra,Kara M. Forsee,Ruth S. MacDonald,Cynthia Besch-Williford,Tim H M Huang,Dennis B. Lubahn +11 more
TL;DR: In this article, the effect of the phytoestrogen genistein on DNA methylation was examined by using mouse differential methylation hybridization arrays to test for changes in the methylation status of the cytosine guanine dinucleotide (CpG) islands in the mouse genome.
Journal ArticleDOI
Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer.
Anna Slusarz,Nader S. Shenouda,Mary S. Sakla,Sara K. Drenkhahn,Acharan S. Narula,Ruth S. MacDonald,Cynthia Besch-Williford,Dennis B. Lubahn +7 more
TL;DR: These botanicals at pharmacologic concentrations are potentially safer and less expensive alternatives to cyclopamine and its pharmaceutical analogues for cancer therapy and are also able to reduce or delay prostate cancer in vivo in TRAMP mice.