R
Ruud Jansen
Publications - 21
Citations - 589
Ruud Jansen is an academic researcher. The author has contributed to research in topics: Legionella & Legionnaires' disease. The author has an hindex of 10, co-authored 20 publications receiving 444 citations.
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Journal ArticleDOI
Understanding and overcoming the pitfalls and biases of next-generation sequencing (NGS) methods for use in the routine clinical microbiological diagnostic laboratory.
TL;DR: The authors provide a general introduction to the most widely used NGS methods currently available and a novel diagnostic microbiota profiling platform (‘MYcrobiota’) is introduced, which was developed by the authors by taking into consideration the pitfalls, biases, and solutions explained in this article.
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High-throughput multilocus sequence typing: bringing molecular typing to the next level.
TL;DR: A high-throughput MLST (HiMLST) method that employs next-generation sequencing (NGS) technology (Roche 454), to generate large quantities of high-quality MLST data at low costs is introduced.
Journal ArticleDOI
Legionnaires’ disease and gardening
J.W. den Boer,Ed P. F. Yzerman,Ruud Jansen,Jacob P. Bruin,L.P.B. Verhoef,G. Neve,K. van der Zwaluw +6 more
TL;DR: The study demonstrated the value of systematic collection of identification data and patient isolates over a prolonged period of Legionnaires' disease patients with indistinguishable genotypes.
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Genotypic comparison of clinical Legionella isolates and patient-related environmental isolates in The Netherlands, 2002-2006
TL;DR: Overall, the distribution of genotypes differed significantly among patient and environmental isolates, suggesting that virulent strains may exist in potential environmental sources at undetectable concentrations.
Journal ArticleDOI
Outbreak detection and secondary prevention of Legionnaires' disease: a national approach.
Jeroen W. Den Boer,L.P.B. Verhoef,Max A. Bencini,Jacob P. Bruin,Ruud Jansen,Ed P. F. Yzerman +5 more
TL;DR: Systematic sampling and cluster recognition can contribute to outbreak detection and lead to cost-effective secondary prevention of Legionnaires' disease.