Ryan Alexander

TL;DR: The transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes is profiled and 175 lncRNAs that are specifically regulated during adipogenesis are identified that are functionally required for proper adipogenesis.

TL;DR: It is demonstrated that a brown-fat-enriched miRNA cluster, MiR-193b–365, serves as an essential regulator for brown fat differentiation, in part by repressing myogenesis.

TL;DR: The role of miRNAs, small endogenously expressed RNAs that regulate gene expression at a post-transcriptional level, in the development and function of adipose tissue and other relevant metabolic tissues impacted by obesity is discussed in this paper.

TL;DR: The roles of miRNAs, small endogenously expressed RNAs that regulate gene expression at a post-transcriptional level, in the development and function of adipose tissue and other relevant metabolic tissues impacted by obesity are discussed.

TL;DR: This study ablated Dgcr8, a key regulator of the miRNA biogenesis pathway, in mature brown as well as in white adipocytes and identified a set of BAT-specific miRNAs that are upregulated during brown adipocyte differentiation and enriched in brown fat compared with other organs.