David L. Silver

TL;DR: For example, AlphaFold as mentioned in this paper predicts protein structures with an accuracy competitive with experimental structures in the majority of cases using a novel deep learning architecture. But the accuracy is limited by the fact that no homologous structure is available.

TL;DR: This work identifies a member of the major facilitator superfamily—Mfsd2a (previously an orphan transporter)—as the major transporter for DHA uptake into brain and reveals an unexpected essential physiological role of plasma-derived LPCs in brain growth and function.

TL;DR: It is reported that in glucogenetic kidney epithelial cells, Pepck and G6p expression are induced by dexamethasone and cAMP, but fail to be inhibited by insulin, consistent with the possibility that Foxo1 is involved in insulin regulation of glucose production by mediating the ability of insulin to decrease the glucocorticoid/cAMP response of G 6p.

TL;DR: The studies provide evidence for a direct interaction between ABC1 and apoA-I, but not HDL, indicating that free apoB-I is the metabolic substrate for ABC1, while cells overexpressing ABC1 displayed a distinctive morphology, characterized by plasma membrane protrusions and resembling echinocytes that form when there are excess lipids in the outer membrane hemileaflet.

TL;DR: The data suggest that the binding of apoA-I to ABCA1 leads to the formation of phospholipid-apoA- I complexes, which subsequently promote cholesterol efflux in an autocrine or paracrine fashion.