Ryoh Tokuda

TL;DR: Newly introduced chiral "roofed" 2-thiazolines, prepared from sterically congested, conformationally rigid chiral 2-aminothiols, function as efficient chiral ligands for the asymmetric Diels-Alder reaction of cyclopentadiene and 3-acryloyl-2-oxazolidinone as discussed by the authors.

TL;DR: In this article, a new class of "roofed" aminothiol derivatives from sterically congested, conformationally rigid chiral 2-thiazolidinones is described.

TL;DR: A functional survey of palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate proved that symmetrical "roofed" β-iminodisulfides are efficient chiral ligands, showing enantioselectivity opposite that associated with chiral "ro ofed"β-im inothioether ligands.

TL;DR: Evaluation of exomethylene acycloguanine nucleosides 4, 6 and its monophosphate derivatives 5, 7, and 8 for anti-HBV activity in HepG2 cells revealed that the phosphonate derivative 8 was found to exhibit moderated activity, but cytotoxicity against the host cells was also observed.