S
Shuhei Imoto
Researcher at Sojo University
Publications - 46
Citations - 435
Shuhei Imoto is an academic researcher from Sojo University. The author has contributed to research in topics: Medicine & Oligonucleotide. The author has an hindex of 12, co-authored 39 publications receiving 356 citations. Previous affiliations of Shuhei Imoto include Tohoku University & Johns Hopkins University.
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DNA tandem lesion repair by strand displacement synthesis and nucleotide excision repair.
TL;DR: The effects of tandem lesions composed of a thymine glycol and a 5'-adjacent 2-deoxyribonolactone or tetrahydrofuran abasic site and bacterial nucleotide excision repair system UvrABC are reported, revealing two solutions that DNA repair systems can use to counteract the formation of tandem lesion.
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Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation
TL;DR: A highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative is reported.
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Alteration of cross-linking selectivity with the 2'-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects.
TL;DR: It has been demonstrated that 2'-OMe oligonucleotides bearing 2 achieve highly selective cross-linking to the thymine base in DNA and show higher antisense effect on luciferase production in cell lysate.
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Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure
Keiki Sakurama,Akito Kawai,Victor Tuan Giam Chuang,Yoko Kanamori,Miyu Osa,Kazuaki Taguchi,Kazuaki Taguchi,Hakaru Seo,Toru Maruyama,Shuhei Imoto,Keishi Yamasaki,Masaki Otagiri +11 more
TL;DR: The mechanism responsible for the binding of ARP to a protein elucidated here should be relevant for assessing the pharmacokinetics and pharmacodynamics of ARp in various clinical situations and for designing new drugs.
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Synthesis, DNA polymerase incorporation, and enzymatic phosphate hydrolysis of formamidopyrimidine nucleoside triphosphates.
TL;DR: The nucleoside triphosphates of N6-(2-deoxy-alpha,beta-d-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine and its C-nucleoside analogue (beta-C-Fapy) and its Fapy.dGTP could be useful for incorporating useful amounts of this nonhydrolyzable analogue for use as an inhibitor