S
S. Eleonore Koehler
Researcher at Maastricht University
Publications - 9
Citations - 338
S. Eleonore Koehler is an academic researcher from Maastricht University. The author has contributed to research in topics: Steatosis & Fatty liver. The author has an hindex of 7, co-authored 9 publications receiving 242 citations.
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Journal ArticleDOI
Pivotal role of glutamine synthetase in ammonia detoxification
Theodorus B. M. Hakvoort,Youji He,Wim Kulik,Jacqueline L.M. Vermeulen,Suzanne Duijst,Jan M. Ruijter,Jurgen H. Runge,Nicolaas E. P. Deutz,S. Eleonore Koehler,Wouter H. Lamers +9 more
TL;DR: The dependence of glutamine‐bound ammonia disposal to urea on the rate of glutamines synthesis suggests that enhancing peripheral glutamine synthesis is a promising strategy to treat hyperammonemia.
Journal ArticleDOI
The growth pattern of the human intestine and its mesentery.
Jelly H. M. Soffers,Jill P. J. M. Hikspoors,Hayelom K. Mekonen,S. Eleonore Koehler,Wouter H. Lamers,Wouter H. Lamers +5 more
TL;DR: It is argued that the concept of “en-bloc rotation” of the developing midgut is a fallacy of schematic drawings, and hypothesize based on published accounts that malrotations result from stunted development of secondary loops.
Journal ArticleDOI
Prevention and reversal of hepatic steatosis with a high-protein diet in mice.
Sonia Garcia-Caraballo,Tine M. Comhair,Fons Verheyen,Ingrid C. Gaemers,Frank G. Schaap,Frank G. Schaap,Sander M. Houten,Theodorus B. M. Hakvoort,Cornelis H. C. Dejong,Wouter H. Lamers,Wouter H. Lamers,S. Eleonore Koehler +11 more
TL;DR: H diets prevent and reverse steatosis independently of fat and carbohydrate intake more efficiently than a 20% reduction in energy intake.
Journal ArticleDOI
Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors
Rom Keshet,Rom Keshet,Joo Sang Lee,Joo Sang Lee,Lital Adler,Muhammed Iraqi,Yarden Ariav,Lisha Qiu Jin Lim,Shaul Lerner,Shiran Rabinovich,Roni Oren,Rotem Katzir,Hila Weiss Tishler,Noa Stettner,Omer Goldman,Hadas Landesman,Sivan Galai,Yael Kuperman,Yuri Kuznetsov,Alexander Brandis,Tevi Mehlman,Sergey Malitsky,Maxim Itkin,S. Eleonore Koehler,Yongmei Zhao,Keyur Talsania,Tsai-wei Shen,Nir Peled,Igor Ulitsky,Angel Porgador,Eytan Ruppin,Ayelet Erez +31 more
TL;DR: It is demonstrated that ASS1 expression under glucose deprivation is induced by c-MYC, providing survival benefit by increasing nitric oxide synthesis and activating the gluconeogenic enzymes pyruvate carboxylase and phosphoenolpyruvATE carboxykinase by S-nitrosylation.
Journal ArticleDOI
Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes
Ramesh Chennupati,Wouter H. Lamers,S. Eleonore Koehler,Jo G. R. De Mey,Jo G. R. De Mey,Jo G. R. De Mey +5 more
TL;DR: In this paper, the effects of aging on the contributions of NO and endothelium-dependent hyperpolarization (EDH) to vascular relaxation in male and female C57BL/6J mice aged 12, 34 and 64 weeks were investigated.