W
Wim Kulik
Researcher at University of Amsterdam
Publications - 52
Citations - 3441
Wim Kulik is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Peroxisome & Asthma. The author has an hindex of 27, co-authored 52 publications receiving 2958 citations.
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Journal ArticleDOI
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
Gang Wang,Megan L. McCain,Luhan Yang,Aibin He,Francesco S. Pasqualini,Ashutosh Agarwal,Hongyan Yuan,Dawei Jiang,Donghui Zhang,Lior Zangi,Judith Geva,Amy E. Roberts,Qing Ma,Jian-Ping Ding,Jinghai Chen,Da-Zhi Wang,Kai Li,Jiwu Wang,Ronald J.A. Wanders,Wim Kulik,Frédéric M. Vaz,Michael A. Laflamme,Charles E. Murry,Kenneth R. Chien,Richard I. Kelley,George M. Church,Kevin Kit Parker,William T. Pu +27 more
TL;DR: This study combined patient-derived and genetically engineered induced pluripotent stem cells (iPSCs) with tissue engineering to elucidate the pathophysiology underlying the cardiomyopathy of Barth syndrome, a mitochondrial disorder caused by mutation of the gene encoding tafazzin (TAZ).
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Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus
Andreas E. Kremer,Job J.W.W. Martens,Wim Kulik,Franziska Ruëff,Edith M. M. Kuiper,Henk R. van Buuren,Karel J. van Erpecum,Jurate Kondrackiene,Jesús Prieto,Christian Rust,Victoria Geenes,Catherine Williamson,Wouter H. Moolenaar,Ulrich Beuers,Ronald P.J. Oude Elferink +14 more
TL;DR: It is suggested that LPA and autotaxin play a critical role in cholestatic pruritus and may serve as potential targets for future therapeutic interventions.
Journal ArticleDOI
The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters
Carlo W.T. van Roermund,Wouter F. Visser,Lodewijk IJlst,Arno van Cruchten,Maxim Boek,Wim Kulik,Hans R. Waterham,Ronald J.A. Wanders +7 more
TL;DR: Data indicate that ALDP can function as a ho modimer and is involved in the transport of acyl‐CoA esters across the peroxisomal membrane, which suggests a role of ALDP in VLCFA import.
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The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study
Alexander P.J. Vlaar,Jorrit J. Hofstra,Rogier M. Determann,Denise P. Veelo,Frederique Paulus,Wim Kulik,Johanna C. Korevaar,Bas A.J.M. de Mol,Marianne M. W. Koopman,Leendert Porcelijn,Jan M. Binnekade,Margreeth B. Vroom,Marcus J. Schultz,Nicole P. Juffermans +13 more
TL;DR: The results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies, as well as transfusion-related morbidity and mortality, in patients with high incidence of TRALI.
Journal ArticleDOI
Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness
Saskia B. Wortmann,Frédéric M. Vaz,Thatjana Gardeitchik,Lisenka E.L.M. Vissers,G. Herma Renkema,Janneke H M Schuurs-Hoeijmakers,Wim Kulik,Martin Lammens,Christin Christin,Leo A. J. Kluijtmans,Richard J. Rodenburg,Leo G.J. Nijtmans,Anne Grünewald,Christine Klein,Joachim M. Gerhold,Tamas Kozicz,Peter M. van Hasselt,Magdalena Harakalova,Wigard P. Kloosterman,Ivo Barić,Ewa Pronicka,Sema Kalkan Uçar,Karin Naess,Kapil K Singhal,Zita Krumina,Christian Gilissen,Hans van Bokhoven,Joris A. Veltman,Jan A.M. Smeitink,Dirk Lefeber,Johannes N. Spelbrink,Johannes N. Spelbrink,Ron A. Wevers,Eva Morava,Arjan P.M. de Brouwer +34 more
TL;DR: Using exome sequencing, SERAC1 mutations are identified as the cause of MEGDEL syndrome, a recessive disorder of dystonia and deafness with Leigh-like syndrome, impaired oxidative phosphorylation and 3-methylglutaconic aciduria.