Yongmei Zhao

TL;DR: Analysis of genetic pathways suggested that MCD and BN2 DLBCLs rely on “chronic active” B‐cell receptor signaling that is amenable to therapeutic inhibition, and an algorithm was developed and implemented to discover genetic subtypes based on the co‐occurrence of genetic alterations.

TL;DR: A draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genomes of the malaria vector Anopheles gambiae was presented in this paper.

TL;DR: This work determined the single-cell transcriptomic landscape of liver cancer biospecimens from 19 patients and found a link between hypoxia-dependent vascular endothelial growth factor expression in tumor diversity and TME polarization.

TL;DR: Evidence is provided that hepatic CSCs at the single‐cell level are phenotypically, functionally, and transcriptomically heterogeneous, and Interestingly, distinct genes within different CSC subpopulations are independently associated with hepatocellular carcinoma prognosis, suggesting that a diverse hepaticCSC transcriptome affects intratumor heterogeneity and tumor progression.

TL;DR: RP-182 as mentioned in this paper is a synthetic 10-mer amphipathic analog of host defense peptides that selectively induces a conformational switch of the mannose receptor CD206 expressed on TAMs displaying an M2-like phenotype.