https://www.just.edu.jo/DIC/ClinicGuidlines/Management%20of%20hip%20and%20knee%20Osteoarthritis.pdf

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

Epstein-Barr virus.

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)60453-5.pdf

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

Haptoglobin is a hemoglobin-binding protein expressed by a genetic polymorphism as three major phenotypes: 1-1, 2-1, and 2-2. Most attention has been paid to determining haptoglobin phenotype as a genetic fingerprint used in forensic medicine. More recently, several functional differences between haptoglobin phenotypes have been demonstrated that appear to have important biological and clinical consequences. Haptoglobin polymorphism is associated with the prevalence and clinical evolution of many inflammatory diseases, including infections, atherosclerosis, and autoimmune disorders. These effects are explained by a phenotype-dependent modulation of oxidative stress and prostaglandin synthesis. Recent evidence is growing that haptoglobin is involved in the immune response as well. The strong genetic pressure favoring the 2-2 phenotype suggests an important role of haptoglobin in human pathology.

Biological and clinical significance of haptoglobin polymorphism in humans.

Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives

Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients with or without joint inflammation.

/pdf/antibodies-against-cyclic-citrullinated-peptide-ccp-in-44qrezwyjt.pdf

Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients with or without joint inflammation

Objectives: To analyse the effects of infliximab infusions on serum levels of lipids in patients with rheumatoid arthritis (RA) treated for 2 years.Methods: Fifty‐two patients (41 females and 11 males) with RA undergoing infliximab treatment (3 mg/kg) were consecutively recruited into the study. The mean (±SD) age of the patients was 54.6±12.5 years and mean disease duration was 14.1±8.6 years. Blood was sampled before infusion at baseline, and at 3, 6, 12, 18 and 24 months. Forty‐one of the patients were also treated with methotrexate, 13 with other disease‐modifying anti‐rheumatic drugs (DMARDs) and 28 with prednisolone (<10 mg daily). For comparison, lipid levels were followed for 2 years in 70 consecutively included patients with early RA during treatment with conventional DMARDs.Results: There was an initial increase in plasma levels of cholesterol, high density lipoprotein (HDL)‐cholesterol, low density lipoprotein (LDL)‐cholesterol, and LDL/HDL and total/HDL cholesterol ratios. However, after 3 mon...

Conversion towards an atherogenic lipid profile in rheumatoid arthritis patients during long‐term infliximab therapy

A longer duration of breastfeeding increased the risk of developing RA, especially among individuals seropositive for ACPA or IgM-RF or carrying the PTPN22 1858T variant. Use of OC for ≥ 7 years wa ...

Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study.

OBJECTIVE: To identify predictors for radiological and functional outcome and bone loss in the hands in early rheumatoid arthritis (RA) during the first 2 yr of disease and to study the relationshi ...

/pdf/predictors-of-radiological-progression-and-changes-in-hand-4xtuvepryn.pdf

Predictors of radiological progression and changes in hand bone density in early rheumatoid arthritis

Serum protein markers (α1-AT, Bf, C3, C4A, C4B, Hp and Tf) were studied in a series of 36 patients with systemic lupus erythematosus (SLE) and compared to normal blood donors. In agreement

S. Rantapää Dahlqvist

Papers

Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients with or without joint inflammation

Conversion towards an atherogenic lipid profile in rheumatoid arthritis patients during long‐term infliximab therapy

Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study.

Predictors of radiological progression and changes in hand bone density in early rheumatoid arthritis

Serum Protein Markers in Systemic Lupus erythematosus