S
S. S. Ratnam
Researcher at University of Chicago
Publications - 116
Citations - 2658
S. S. Ratnam is an academic researcher from University of Chicago. The author has contributed to research in topics: Pregnancy & Population. The author has an hindex of 25, co-authored 116 publications receiving 2583 citations. Previous affiliations of S. S. Ratnam include University of Pittsburgh & National University of Singapore.
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Journal ArticleDOI
The sperm centriole: its inheritance, replication and perpetuation in early human embryos
TL;DR: It is evident that the sperm centrosomes is the functional active centrosome in human, while the female is inactive but may contribute some centrosomal material to the zygote centrosite.
Journal ArticleDOI
Dynamics of Dnmt1 methyltransferase expression and intracellular localization during oogenesis and preimplantation development.
S. S. Ratnam,Carmen Mertineit,Feng Ding,Carina Howell,Hugh J. Clarke,Timothy H. Bestor,J. Richard Chaillet,Jacquetta M. Trasler +7 more
TL;DR: The highly restricted nuclear localization patterns of oocyte-derived Dnmt1o and DnMT1 during preimplantation development add further support to the notion that DNA methyltransferases other than Dn mt1 are required for maintaining imprints during pre- and postimplantations development.
Journal ArticleDOI
Centrioles in the beginning of human development.
A.H. Sathananthan,Ismail Kola,J Osborne,Alan O Trounson,Soon-Chye Ng,Ariff Bongso,S. S. Ratnam +6 more
TL;DR: The data provide evidence that human centrioles, as those in most other animals, and unlike the mouse, are paternally derived, thus supporting Boveri's classical theory.
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Abnormal Regulation of DNA Methyltransferase Expression in Cloned Mouse Embryos
TL;DR: It is found that cloned preimplantation mouse embryos aberrantly express the somatic form of the Dnmt1 DNA (cytosine-5) methyltransferase, the expression of which is normally prevented by a posttranscriptional mechanism.
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Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints
TL;DR: It is suggested that Dnmt1s provides maintenance methyltransferase activity for the inheritance of methylation imprints in the early mouse embryo and the developmental source is the critical determinant of DnMT1 function during preimplantation development.