S
S T Freer
Researcher at University of California, San Diego
Publications - 16
Citations - 2668
S T Freer is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Dihydrofolate reductase & Hydrogen bond. The author has an hindex of 15, co-authored 16 publications receiving 2641 citations.
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Journal ArticleDOI
Chymotrypsinogen: 2.5-angstrom crystal structure, comparison with alpha-chymotrypsin, and implications for zymogen activation.
Journal ArticleDOI
Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate.
D A Matthews,R A Alden,Jeffrey T. Bolin,S T Freer,R Hamlin,Nguyen-Huu Xuong,Joseph Kraut,Martin Poe,Myra N. Williams,Karst Hoogsteen +9 more
TL;DR: A central eight-stranded beta-pleated sheet is the main feature of the polypeptide backbone folding in dihydrofolate reductase, and Methotrexate is bound in a 15-angstrom-deep cavity with the pteridine ring buried in a primarily hydrophobic pocket.
Journal ArticleDOI
The crystal structure of cytochrome c peroxidase.
Thomas L. Poulos,S T Freer,R A Alden,Steven L. Edwards,U Skogland,K Takio,B Eriksson,Nguyen-Huu Xuong,Takashi Yonetani,Joseph Kraut +9 more
TL;DR: Partial sequence information that has recently become available aided in completion of the tracing of the polypeptide backbone, confirmed the presence of a proximal histidine heme ligand and aided in identification of tryptophan, histidine, and arginine side chains close to the sixth coordination position of the heme.
Journal ArticleDOI
Two-Angstrom crystal structure of oxidized Chromatium high potential iron protein.
TL;DR: The 85-residue structure of Chromatium high potential iron protein has been determined by x-ray diffraction methods at 2.0 A resolution, and is currently undergoing crystallographic refinement, which is an unusually well determined protein structure.