S
S. W. Brouilette
Researcher at University of Leicester
Publications - 12
Citations - 1903
S. W. Brouilette is an academic researcher from University of Leicester. The author has contributed to research in topics: Offspring & Telomere. The author has an hindex of 10, co-authored 12 publications receiving 1808 citations.
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Journal ArticleDOI
Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
S. W. Brouilette,Jasbir S. Moore,Alex D. McMahon,John R. Thompson,Ian Ford,James Shepherd,Chris J. Packard,Nilesh J. Samani +7 more
TL;DR: In this article, the authors investigated whether mean leucocyte telomere length is a predictor of the development of coronary heart disease and found that individuals in the middle and lowest tertiles of telomeres were more at risk of developing a heart disease event than those in the highest tertile.
Journal ArticleDOI
White Cell Telomere Length and Risk of Premature Myocardial Infarction
TL;DR: The findings support the concept that biological age may play a role in the etiology of coronary heart disease and have potentially important implications for the understanding of its genetic etiology, pathogenesis, and variable age of onset.
Journal ArticleDOI
Mapping of a Major Locus that Determines Telomere Length in Humans
Mariuca Vasa-Nicotera,S. W. Brouilette,Massimo Mangino,John R. Thompson,Peter S. Braund,Jenny-Rebecca Clemitson,Andrea Mason,Clare L. Bodycote,Stuart M Raleigh,Edward J. Louis,Nilesh J. Samani +10 more
TL;DR: Mapping of the first locus that determines mean telomere length in humans is reported, and preliminary analysis of a strong candidate gene in the region, the DNA helicase DDX11, is presented.
Journal ArticleDOI
Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis
S. W. Brouilette,Andrew Whittaker,Suzanne Stevens,van der Pim Harst,Alison H. Goodall,Nilesh J. Samani +5 more
TL;DR: In this article, the authors investigated whether shorter telomeres are a primary abnormality or secondary to coronary artery disease in healthy young adults with contrasting familial risk of CAD and found a decrease in mean telomere restriction fragment (TRF) length in DNA from circulating leucocytes.
Journal ArticleDOI
A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans
Massimo Mangino,S. W. Brouilette,Peter S. Braund,Nighat Tirmizi,Mariuca Vasa-Nicotera,John R. Thompson,Nilesh J. Samani +6 more
TL;DR: A genome-wide linkage analysis of mean leukocyte telomere length and fine-mapping identified a 51 kb region of association within intron 1 of the Bicaudal-D homolog 1 (BICD 1, MIM 602204) gene, indicating that BICD1 plays a similar role in humans.