J
James Shepherd
Researcher at University of Glasgow
Publications - 98
Citations - 26107
James Shepherd is an academic researcher from University of Glasgow. The author has contributed to research in topics: Pravastatin & Atorvastatin. The author has an hindex of 42, co-authored 85 publications receiving 23953 citations. Previous affiliations of James Shepherd include Glasgow Royal Infirmary.
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Journal ArticleDOI
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
James Shepherd,Gerard J. Blauw,Michael B. Murphy,Edward L.E.M. Bollen,Brendan M. Buckley,Stuart M. Cobbe,Ian Ford,Allan Gaw,Michael E. Hyland,J. Wouter Jukema,Adriaan M. Kamper,Peter W. Macfarlane,A. Edo Meinders,John Norrie,Chris J. Packard,Ivan J. Perry,David J. Stott,Brian Sweeney,Gillian Twomey,Rudi G. J. Westendorp +19 more
TL;DR: Pravastatin given for 3 years reduced the risk of coronary disease in elderly individuals and was extended to elderly individuals the treatment strategy currently used in middle aged people.
Journal ArticleDOI
Intensive lipid lowering with atorvastatin in patients with stable coronary disease.
John C. LaRosa,Scott M. Grundy,David D. Waters,Charles L. Shear,Philip J. Barter,Jean Charles Fruchart,Antonio M. Gotto,Heiner Greten,John J.P. Kastelein,James Shepherd,Nanette K. Wenger +10 more
TL;DR: Intensive lipid-lowering therapy with 80 mg of atorvastatin per day in patients with stable CHD provides significant clinical benefit beyond that afforded by treatment with 10 mg of least-in- LDL cholesterol levels per day, with a greater incidence of elevated aminotransferase levels.
Journal ArticleDOI
European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice.
Guy De Backer,Ettore Ambrosioni,Knut Borch-Johnsen,Carlos Brotons,Renata Cifkova,Jean Dallongeville,Shah Ebrahim,Ole Faergeman,Ian D. Graham,Giuseppe Mancia,Volkert Manger Cats,Kristina Orth-Gomér,Joep Perk,Kalevi Pyörälä,Jose L. Rodicio,Susana Sans,Vedat Sansoy,Udo Sechtem,Sigmund Silber,Troels Thomsen,David R. Wood,Christian Albus,Nuri Bages,Gunilla Burell,Ronan M. Conroy,Hans Christian Deter,Christoph Hermann-Lingen,Steven Humphries,Anthony Fitzgerald,Brian Oldenburg,Neil Schneiderman,Antti Uutela,Redford Williams,John Yarnell,Silvia G. Priori,Maria Angeles Alonso Garcia,Jean-Jacques Blanc,Andrzej Budaj,Martin R. Cowie,Veronica Dean,Jaap W. Deckers,Enrique Fernandez Burgos,John Lekakis,Bertil Lindahl,Gianfranco Mazzotta,Keith McGregor,João Morais,Ali Oto,Otto A. Smiseth,Hans-Joachim Trappe,Carl-David Agardh,Jean-Pierre Bassand,Maciek Godycki-Cwirko,Anthony M. Heagerty,Robert J. Heine,Philip Home,Silvia Priori,Pekka Puska,Mike Rayner,Annika Rosengren,Mario Sammut,James Shepherd,Johannes Siegrist,Maarten L. Simoons,Michal Tendera,Alberto Zanchetti +65 more
TL;DR: It is of great importance that guidelines and recommendations are presented in formats that are easily interpreted, and their implementation programmes must also be well conducted.
Journal ArticleDOI
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
Naveed Sattar,David Preiss,Heather Murray,Paul Welsh,Brendan M. Buckley,Anton J. M. de Craen,Sreenivasa Rao Kondapally Seshasai,John J.V. McMurray,Dilys J. Freeman,J. Wouter Jukema,Peter W. Macfarlane,Chris J. Packard,David J. Stott,Rudi G. J. Westendorp,James Shepherd,Barry R. Davis,Sara L. Pressel,Roberto Marchioli,Rosa Maria Marfisi,Aldo P. Maggioni,Luigi Tavazzi,Gianni Tognoni,John Kjekshus,Terje R. Pedersen,Thomas J. Cook,Antonio M. Gotto,Michael Clearfield,John R. Downs,Haruo Nakamura,Yasuo Ohashi,Kyoichi Mizuno,Kausik K. Ray,Ian Ford +32 more
TL;DR: A meta-analysis of published and unpublished data found that statin therapy is associated with a slightly increased risk of development of diabetes, but the risk is low both in absolute terms and when compared with the reduction in coronary events.