S
Saartje Burgmans
Researcher at Maastricht University
Publications - 30
Citations - 1452
Saartje Burgmans is an academic researcher from Maastricht University. The author has contributed to research in topics: Dementia & Cognitive decline. The author has an hindex of 17, co-authored 30 publications receiving 1113 citations. Previous affiliations of Saartje Burgmans include European Graduate School.
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Journal ArticleDOI
Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease
Harm J. van de Haar,Saartje Burgmans,Jacobus F.A. Jansen,Matthias J.P. van Osch,Mark A. van Buchem,Majon Muller,Paul A. M. Hofman,Frans R.J. Verhey,Walter H. Backes +8 more
TL;DR: The results of this study showed global BBB leakage in patients with early AD that is associated with cognitive decline that may be part of a cascade of pathologic events that eventually lead to cognitive decline and dementia.
Journal ArticleDOI
Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease (vol 281, pg 527, 2016)
Harm J. van de Haar,Saartje Burgmans,Jacobus F.A. Jansen,Matthias J.P. van Osch,Mark A. van Buchem,Majon Muller,Paul Hofman,Frans R.J. Verhey,Walter H. Backes +8 more
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Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging
Harm J. van de Haar,Jacobus F.A. Jansen,Matthias J.P. van Osch,Mark A. van Buchem,Majon Muller,Sau May Wong,Paul A. M. Hofman,Saartje Burgmans,Frans R.J. Verhey,Walter H. Backes +9 more
TL;DR: The patients with early AD showed significantly lower CBF and local blood volume in the gray matter, compared with controls, and it is found that a reduction in CBF is correlated with an increase in leakage rate, which supports the hypothesis that neurovascular damage, and in particular impairment of the neurov vascular unit constitutes the pathophysiological link between CBF reduction and BBB impairment in AD.
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Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer’s disease
Carmen Echavarri,Pauline Aalten,Harry B.M. Uylings,Harry B.M. Uylings,Heidi I.L. Jacobs,Pieter Jelle Visser,Pieter Jelle Visser,Ed H.B.M. Gronenschild,Frans R.J. Verhey,Saartje Burgmans +9 more
TL;DR: The results suggest that parahippocampal volume discriminates better than hippocampal volume between cases of healthy aging, aMCI, and mild AD, in particular, in the early phase of the disease.
Journal ArticleDOI
Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension.
Saartje Burgmans,M.P.J. van Boxtel,M.P.J. van Boxtel,Ed H.B.M. Gronenschild,Ed H.B.M. Gronenschild,Eric F. P. M. Vuurman,Eric F. P. M. Vuurman,Paul A. M. Hofman,Paul A. M. Hofman,Harry B.M. Uylings,Harry B.M. Uylings,Harry B.M. Uylings,Jelle Jolles,Jelle Jolles,Jelle Jolles,Naftali Raz +15 more
TL;DR: Findings indicate that of all examined measures, diffusion-based indices of white matter integrity may be the most sensitive indicators of global and regional declines and vascular damage in the aging brain.