S
Sabine Ameling
Researcher at Greifswald University Hospital
Publications - 33
Citations - 782
Sabine Ameling is an academic researcher from Greifswald University Hospital. The author has contributed to research in topics: Dilated cardiomyopathy & Medicine. The author has an hindex of 11, co-authored 24 publications receiving 623 citations. Previous affiliations of Sabine Ameling include University of Greifswald.
Papers
More filters
Journal ArticleDOI
Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation
Oliver Adam,Daniel Lavall,Katharina Theobald,Mathias Hohl,Markus Grube,Sabine Ameling,Mark A. Sussman,Stephan Rosenkranz,Heyo K. Kroemer,Hans-Joachim Schäfers,Michael Böhm,Ulrich Laufs +11 more
TL;DR: Transcriptional profiling of left atrial myocardium from patients with AF showed a marked up-regulation of connective tissue growth factor (CTGF) expression compared with sinus rhythm patients, identifying CTGF as an important mediator of atrial structural remodeling during AF.
Journal ArticleDOI
Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study
Sabine Ameling,Tim Kacprowski,Ravi Kumar Chilukoti,Carolin Malsch,Volkmar Liebscher,Karsten Suhre,Maik Pietzner,Nele Friedrich,Georg Homuth,Elke Hammer,Uwe Völker +10 more
TL;DR: It is emphasized that circulating miRNAs are strongly impacted by age, BMI, and sex, and these parameters should be considered as covariates in association studies based on plasma miRNA levels.
Journal ArticleDOI
Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation
Oliver Adam,Katharina Theobald,Daniel Lavall,Markus Grube,Heyo K. Kroemer,Sabine Ameling,Hans-Joachim Schäfers,Michael Böhm,Ulrich Laufs +8 more
TL;DR: Left atrial myocardium of patients with atrial fibrillation is characterized by increased lysyl oxidase and fibronectin expression as well as collagen cross-linking, and inhibition of this signaling pathway may represent a target for the prevention of fibrotic atrial remodeling.
Journal ArticleDOI
Characterization of the human myocardial proteome in inflammatory dilated cardiomyopathy by label-free quantitative shotgun proteomics of heart biopsies
Elke Hammer,Michelle Goritzka,Sabine Ameling,Katrin Darm,Leif Steil,Karin Klingel,Christiane Trimpert,Lars R. Herda,Marcus Dörr,Heyo K. Kroemer,Reinhard Kandolf,Alexander Staudt,Stephan B. Felix,Uwe Völker +13 more
TL;DR: This study demonstrates that label-free, mass spectrometry-centered approaches can identify disease dependent alterations in the proteome from small tissue samples such as endomyocardial biopsies, which might allow better disease characterization and may be a valuable tool in potential clinical proteomic studies.
Journal ArticleDOI
Selective Regulation of Cardiac Organic Cation Transporter Novel Type 2 (OCTN2) in Dilated Cardiomyopathy
Markus Grube,Sabine Ameling,Michel Noutsias,Kathleen Köck,Ivonne Triebel,Karina Bonitz,Konrad Meissner,Gabriele Jedlitschky,Lars R. Herda,Markus Reinthaler,Maria Rohde,Wolfgang Hoffmann,Uwe Kühl,Heinz-Peter Schultheiss,Uwe Völker,Stephan B. Felix,Karin Klingel,Reinhard Kandolf,Heyo K. Kroemer +18 more
TL;DR: OCTN2 expression is selectively reduced in dilated cardiomyopathy patients and predicts the impairment of cardiac function, and a specific drug-interaction profile with pronounced inhibition of OCT1 function is revealed.