Sabine Buchmeier

TL;DR: These findings suggest that the interaction of PFN II with SMN may be involved in neuron-specific effects of SMN mutations, the primary target of neurodegeneration in SMA.

TL;DR: It is concluded that 2G2, in addition to binding to SDS- and methanol-denatured actin, recognises a specific conformation of native actin which is present in the nucleus and specified by compaction of the antibody-reactive region into a coherent patch.

TL;DR: It is indicated that distinct actin conformations and/or structures are present in the nucleus and the cytoplasm of different cell types and that their distribution varies in response to external signals.

TL;DR: Mutational analysis shows that key residues important for guide-dependent target processing are also involved in guide-independent MjAgo function, the first characterization of guide- independent cleavage activity for an Argonaute protein potentially serving as a guide biogenesis pathway in a prokaryotic system.

TL;DR: These studies indicate that self-assembling peptide nanoparticles represent a versatile platform that can easily be customized to present antigenic determinants in repetitive, ordered arrays and elicit an immune response against poor antigens.