S
Sacha B. Nelson
Researcher at Brandeis University
Publications - 140
Citations - 30371
Sacha B. Nelson is an academic researcher from Brandeis University. The author has contributed to research in topics: Visual cortex & Excitatory postsynaptic potential. The author has an hindex of 68, co-authored 134 publications receiving 27897 citations. Previous affiliations of Sacha B. Nelson include Salk Institute for Biological Studies & Center for Neural Science.
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Hebb and homeostasis in neuronal plasticity.
TL;DR: It is suggested that Hebbian and homeostatic plasticity often target the same molecular substrates, and have opposing effects on synaptic or neuronal properties, and significantly broaden the framework for understanding the effects of activity on synaptic function and neuronal excitability.
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Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome.
Vardhan S. Dani,Qiang Chang,Arianna Maffei,Gina G. Turrigiano,Rudolf Jaenisch,Sacha B. Nelson +5 more
TL;DR: It is shown that spontaneous activity of pyramidal neurons is reduced in Mecp2-mutant mice and the balance between cortical excitation and inhibition is shifted to favor inhibition over excitation, providing a framework for understanding the pathophysiology of the disease and tools for studying the underlying disease mechanisms.
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Neocortical LTD via Coincident Activation of Presynaptic NMDA and Cannabinoid Receptors
TL;DR: TLTD requires simultaneous activation of presynaptic NMDA and CB1 receptors and this novel form of coincidence detection may explain the temporal window of tLTD and may also impart synapse specificity to cannabinoid retrograde signaling.
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A Quantitative Description of Short-Term Plasticity at Excitatory Synapses in Layer 2/3 of Rat Primary Visual Cortex
Juan A. Varela,Kamal Sen,Jay R. Gibson,Jay R. Gibson,Joshua Fost,Larry F. Abbott,Sacha B. Nelson +6 more
TL;DR: The results indicate that firing evoked by visual stimuli is likely to cause significant depression at cortical synapses, and synaptic depression may be an important determinant of the temporal features of visual cortical responses.
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Critical periods for experience-dependent synaptic scaling in visual cortex.
TL;DR: The data indicate that mEPSC amplitudes can be globally scaled up or down as a function of development and sensory experience, and suggest that synaptic scaling may be involved in the activity-dependent refinement of cortical connectivity.