S
Sakae Obara
Researcher at Shin-Etsu Chemical
Publications - 34
Citations - 1095
Sakae Obara is an academic researcher from Shin-Etsu Chemical. The author has contributed to research in topics: Extrusion & Enteric coating. The author has an hindex of 13, co-authored 34 publications receiving 1001 citations.
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Journal ArticleDOI
Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion.
Michael M. Crowley,Britta Schroeder,Anke Fredersdorf,Sakae Obara,Mark Talarico,Shawn A. Kucera,James W. McGinity +6 more
TL;DR: The Higuchi diffusion model, Percolation Theory and Polymer Free Volume Theory were applied to the dissolution data to explain the release properties of drug from the matrix systems and the release rate was shown to be dependent on the ethyl cellulose particle size, compaction force and extrusion temperature.
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Evaluation of hypromellose acetate succinate (HPMCAS) as a carrier in solid dispersions.
TL;DR: Hypromellose acetate succinate showed the highest drug dissolution level from its solid dispersion in a dissolution study using a buffer of pH 6.8, and the inhibitory effect of HPMCAS on recrystallization of NP from a supersaturated solution was the greatest among all the polymers examined.
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Dry coating: an innovative enteric coating method using a cellulose derivative.
TL;DR: The results show that this dry coating method is applicable to the preparation of enteric-coated beads and tablets using commercially available lab-scale apparatus.
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Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: Polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs
TL;DR: HMM drug-polymer systems that prevent drug nucleation by staying below critical supersaturation are more effective for partitioning than those that achieve the highest supersaturation.
Journal ArticleDOI
Stability assessment of hypromellose acetate succinate (HPMCAS) NF for application in hot melt extrusion (HME).
Ashish L. Sarode,Sakae Obara,Fumie Tanno,Harpreet K. Sandhu,Raman Mahadevan Iyer,Navnit Hargovindas Shah +5 more
TL;DR: The HME processing conditions for solid dispersions of HPMCAS should be based on the acceptance levels of free acid for the drug and the drug product.