M
Michael M. Crowley
Researcher at University of Texas at Austin
Publications - 14
Citations - 1490
Michael M. Crowley is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Differential scanning calorimetry & Hildebrand solubility parameter. The author has an hindex of 9, co-authored 14 publications receiving 1374 citations.
Papers
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Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion.
Michael M. Crowley,Britta Schroeder,Anke Fredersdorf,Sakae Obara,Mark Talarico,Shawn A. Kucera,James W. McGinity +6 more
TL;DR: The Higuchi diffusion model, Percolation Theory and Polymer Free Volume Theory were applied to the dissolution data to explain the release properties of drug from the matrix systems and the release rate was shown to be dependent on the ethyl cellulose particle size, compaction force and extrusion temperature.
Journal ArticleDOI
Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion
TL;DR: Drug release rates from hot-melt extruded tablets stabilized with antioxidants were found to be dependent on the hydrophilic nature of the antioxidant.
Journal ArticleDOI
The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films.
Michael M. Crowley,Anke Fredersdorf,Britta Schroeder,Shawn A. Kucera,Suneela Prodduturi,Michael A. Repka,James W. McGinity +6 more
TL;DR: Guaifenesin and ketoprofen were found to decrease drive load, increase PEO stability and plasticize the polymer during extrusion, and the Hansen solubility parameters predicted miscibility between PEO and KTP and poor miscibilitybetween PEOand GFN.
Journal ArticleDOI
The use of near-infrared spectroscopy for the quantitation of a drug in hot-melt extruded films
Sri Venkata S Tumuluri,Suneela Prodduturi,Michael M. Crowley,Steven P. Stodghill,James W. McGinity,Michael A. Repka,Bonnie A. Avery +6 more
TL;DR: These studies clearly demonstrate that NIRS is a powerful method for the quantitation of active drug substances contained in films produced by HME and warrants further investigation.