Sakashi Nomura

TL;DR: Subtype-specific antibodies were used for immunohistochemistry combined with lesioning of the three major hippocampal pathways to establish the precise localization of presynaptic mGluRs in the rat hippocampus, suggesting that transmitter release is differentially regulated by 2-amino-4-phosphonobutyrate-sensitive mGLURs in individual synapses on single axons according to the identity of postsynaptic neurons.

TL;DR: The coupled oxidation method, when applied to the histochemical demonstration of HRP in combination with cobalt method 1, was found to give excellent electron microscopical pictures of the electron dense reaction product.

TL;DR: A trpE-fusion protein containing a C-terminal sequence of a rat metabotropic glutamate receptor, mGluR5, was used to produce an antibody as mentioned in this paper.

TL;DR: The mutant mice performed normally in water maze learning tasks and the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber—CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.

TL;DR: The present results indicate that the localization of mGLUR3 is rather similar to that of group I mGluRs in the postsynaptic elements, suggesting a unique functional role of m GluR3 in glutamatergic neurotransmission in the CNS.