Salina Louie

TL;DR: It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.

TL;DR: Thymocytes lacking pannexin-1, but not the P2X7R purinergic receptor, were defective in their uptake of the nucleic acid dye YO-PRO-1 during early apoptosis, consistent with pannexIn-1 liberating ATP and other yet to be defined “find me” signals necessary for macrophage recruitment to apoptotic cells.

TL;DR: Phosphorylation of NLRC4 S533 probably drives conformational changes necessary forNLRC4 inflammasome activity and host innate immunity.

TL;DR: Generation and use of a FX knockout (FXKO) CHO host cell line that is capable of expressing antibody molecules with either primarily fucosylated or fully afucOSylated glycan profiles with otherwise similar product quality attributes, depending on addition of fucose to the cell culture media is reported.

TL;DR: The results demonstrate that in the presence of selection agent, the Poisson distribution of all cells clearly underestimates the probability of obtaining clonally‐derived cell lines.