David H. Hackos

TL;DR: Thymocytes lacking pannexin-1, but not the P2X7R purinergic receptor, were defective in their uptake of the nucleic acid dye YO-PRO-1 during early apoptosis, consistent with pannexIn-1 liberating ATP and other yet to be defined “find me” signals necessary for macrophage recruitment to apoptotic cells.

TL;DR: A novel protein-engineering strategy is devised that overcomes the technical complexities of producing full-length human Nav channels and demonstrates how this important new class of gating modifier engages VSD4 to inhibit Nav channel activity through a “voltage-sensor trapping” mechanism.

TL;DR: The identification of a new NMDAR modulatory site and characterization of GluN2A-selective PAMs provide powerful molecular tools to dissect N MDAR function and demonstrate the feasibility of a therapeutically desirable type of NMD AR enhancement.

TL;DR: The recent progress, unsettled issues, and challenges in TRPA1 research and drug discovery are reviewed.

TL;DR: Structures reveal how activation of voltage-gated sodium channels causes conformational changes in a voltage-sensor domain, leading to fast inactivation, and pharmacological trapping of VSD4 reveals state-dependent interactions of gating charges from the S4 helix and S4-S5 linker.