John B. Lowe

TL;DR: This review focuses on the biological functions of mammalian fucosylated glycans and the biosynthetic processes leading to formation of the fucOSylated glycan precursor GDP-fucose, a deoxyhexose that is present in a wide variety of organisms.

TL;DR: This work has developed a method that uses secondary ion mass spectrometry to image antibodies tagged with isotopically pure elemental metal reporters to provide new insights into disease pathogenesis that will be valuable for basic research, drug discovery and clinical diagnostics.

TL;DR: It is demonstrated here that mice deficient in alpha(1,3) fucosyltransferase Fuc-TVII exhibit a leukocyte adhesion deficiency characterized by absent leukocytes E- and P-selectin ligand activity and deficient HEV L- selectin ligands activity.

TL;DR: It is demonstrated that transfection of a human fucosyltransferase cDNA into nonmyeloid cell lines confers ELAM-1--dependent endothelial adhesion, and it is proposed that specific alpha(1,3)fucOSyltransferases regulate cell adhesion to ELam-1 by modulating cell surface expression of one or more alpha(2,3).

TL;DR: A review of recent studies analyzing function of a variety of glycoconjugates, focusing on lessons learned from human disease and genetic studies in mice, Drosophila melanogaster, and Caenorhabditis elegans, suggests that O-fucose, O-mannose, N-glycans, mucin-type O-gly cans and proteoglycans are likely to play important roles in developmental processes.