S
Samantha B. Larsen
Researcher at Howard Hughes Medical Institute
Publications - 12
Citations - 1136
Samantha B. Larsen is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Stem cell & Regenerative medicine. The author has an hindex of 9, co-authored 11 publications receiving 741 citations. Previous affiliations of Samantha B. Larsen include New York University & University of Pittsburgh.
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Journal ArticleDOI
Inflammatory memory sensitizes skin epithelial stem cells to tissue damage
Shruti Naik,Samantha B. Larsen,Nicholas C. Gomez,Kirill Alaverdyan,Ataman Sendoel,Shaopeng Yuan,Lisa Polak,Anita Kulukian,Sophia Chai,Elaine Fuchs +9 more
TL;DR: A prolonged memory to acute inflammation is reported that enables mouse EpSCs to hasten barrier restoration after subsequent tissue damage, and this functional adaptation does not require skin-resident macrophages or T cells.
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Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
Rene C. Adam,Hanseul Yang,Shira Rockowitz,Samantha B. Larsen,Maria Nikolova,Daniel S. Oristian,Lisa Polak,Meelis Kadaja,Amma Asare,Deyou Zheng,Elaine Fuchs +10 more
TL;DR: It is shown that super-enhancers underlie the identity, lineage commitment and plasticity of adult stem cells in vivo, and that when outside their niche, either in vitro or in wound-repair, hair follicle stem cells dynamically remodel super- enhancers in response to changes in their microenvironment.
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Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease.
TL;DR: Drawing parallels between different stem cell niches is drawn to explore the context-specific interactions that stem cells have with tissue-resident and recruited immune cells and highlight stem cells' innate ability to sense and respond to stress and the enduring memory that forms from such encounters.
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Epithelial cells: liaisons of immunity
TL;DR: The recent literature on how epithelial cells sense signals from microbes, allergens, and injury at the tissue surface, and transmit this information to immune cells, while embedding a memory of the experience within their chromatin are reviewed.
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Establishment, maintenance, and recall of inflammatory memory.
Samantha B. Larsen,Samantha B. Larsen,Christopher J. Cowley,Sairaj M. Sajjath,Douglas Barrows,Yihao Yang,Thomas L. Carroll,Elaine Fuchs +7 more
TL;DR: In this paper, the authors investigate the role of stress-responsive transcription factors in memory recall and re-recruitment in the context of inflammatory memory. But, their work is limited to a single cell type and does not consider other types of cells.