S
Shaopeng Yuan
Researcher at Howard Hughes Medical Institute
Publications - 23
Citations - 2767
Shaopeng Yuan is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Stem cell & Mucus. The author has an hindex of 14, co-authored 18 publications receiving 2095 citations. Previous affiliations of Shaopeng Yuan include Memorial Sloan Kettering Cancer Center & Cardiovascular Institute Hospital.
Papers
More filters
Journal ArticleDOI
A Distinct Function of Regulatory T Cells in Tissue Protection
Nicholas Arpaia,Jesse A. Green,Bruno Moltedo,Aaron Arvey,Saskia Hemmers,Shaopeng Yuan,Piper M. Treuting,Alexander Y. Rudensky +7 more
TL;DR: The results suggest that, during infectious lung injury, Treg cells have a major direct and non-redundant role in tissue repair and maintenance-distinct from their role in suppression of immune responses and inflammation-and that these two essential Treg cell functions are invoked by separable cues.
Journal ArticleDOI
Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma
Sukhvinder Sidhu,Shaopeng Yuan,Anh L. Innes,Sheena C. Kerr,Prescott G. Woodruff,Lydia Hou,Susan J. Muller,John V. Fahy +7 more
TL;DR: Epithelial cell-derived periostin in asthma has roles in TGF-β activation and collagen gel elasticity in asthma and alters collagen fibrillogenesis or cross-linking and leads to stiffening of the matrix.
Journal ArticleDOI
Inflammatory memory sensitizes skin epithelial stem cells to tissue damage
Shruti Naik,Samantha B. Larsen,Nicholas C. Gomez,Kirill Alaverdyan,Ataman Sendoel,Shaopeng Yuan,Lisa Polak,Anita Kulukian,Sophia Chai,Elaine Fuchs +9 more
TL;DR: A prolonged memory to acute inflammation is reported that enables mouse EpSCs to hasten barrier restoration after subsequent tissue damage, and this functional adaptation does not require skin-resident macrophages or T cells.
Journal ArticleDOI
Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma
Michael C. Peters,Zesemayat K. Mekonnen,Shaopeng Yuan,Nirav R. Bhakta,Prescott G. Woodruff,John V. Fahy +5 more
TL;DR: In this paper, gene profiling in sputum cells was used to identify T H 2-high and T h 2-low subtypes of asthma using the 3-gene signature of periostin, CLCA1, and SERPINB2 in airway epithelial brushings.
Journal ArticleDOI
Stem Cell Lineage Infidelity Drives Wound Repair and Cancer
Yejing Ge,Nicholas C. Gomez,Rene C. Adam,Maria Nikolova,Hanseul Yang,Akanksha Verma,Catherine P. Lu,Lisa Polak,Shaopeng Yuan,Olivier Elemento,Elaine Fuchs +10 more
TL;DR: It is found that breakdown of stem cell lineage confinement-granting privileges associated with both fates-is not only hallmark but also functional in cancer development and shows that lineage plasticity is critical in wound repair, where it operates transiently to redirect fates.