S
Samantha M. Bevill
Researcher at University of North Carolina at Chapel Hill
Publications - 12
Citations - 248
Samantha M. Bevill is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Chromatin & Enhancer. The author has an hindex of 5, co-authored 10 publications receiving 169 citations. Previous affiliations of Samantha M. Bevill include Broad Institute & Harvard University.
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Journal ArticleDOI
Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex
Jon S. Zawistowski,Samantha M. Bevill,Daniel R. Goulet,Timothy J. Stuhlmiller,Adriana S. Beltran,Jose F. Olivares-Quintero,Darshan Singh,Noah Sciaky,Joel S. Parker,Naim U. Rashid,Xin Chen,James S. Duncan,Martin C. Whittle,Steven P. Angus,Sara H. Velarde,Brian T. Golitz,Xiaping He,Charlene M. Santos,David B. Darr,Kristalyn K. Gallagher,Lee M. Graves,Charles M. Perou,Lisa A. Carey,H. Shelton Earp,Gary L. Johnson +24 more
TL;DR: Widespread transcriptional adaptation to pharmacologic MEK inhibition was observed in TNBC patient tumors, and pharmacologic targeting of P-TEFb members in conjunction with MEK inhibited by trametinib is an effective strategy to durably inhibit epigenomic remodeling required for adaptive resistance.
Journal ArticleDOI
GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.
Samantha M. Bevill,Jose F. Olivares-Quintero,Noah Sciaky,Brian T. Golitz,Darshan Singh,Adriana S. Beltran,Naim U. Rashid,Timothy J. Stuhlmiller,Andrew E. Hale,Nathaniel J. Moorman,Charlene M. Santos,Steven P. Angus,Jon S. Zawistowski,Gary L. Johnson +13 more
TL;DR: GSK2801 blocks BRD2-driven transcription in combination with BET inhibitor and induces apoptosis of TNBC by a combinatorial suppression of ribosomal DNA transcription and ETS-regulated genes.
Journal ArticleDOI
Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.
Amanda E.D. Van Swearingen,Maria J. Sambade,Marni B. Siegel,Shivani Sud,Robert S. McNeill,Samantha M. Bevill,Xin Chen,Ryan E. Bash,Louisa A. Mounsey,Brian T. Golitz,Charlene M. Santos,Allison M. Deal,Joel S. Parker,Naim U. Rashid,C. Ryan Miller,Gary L. Johnson,Carey K. Anders +16 more
TL;DR: Results demonstrate that rational combinations of the clinically available inhibitors selumetinib with buparlisib or pazopanib may prove to be promising therapeutic strategies for the treatment of some TNBC brain metastases.
Journal ArticleDOI
Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells.
Sarah J. Shareef,Sarah J. Shareef,Samantha M. Bevill,Samantha M. Bevill,Ayush T. Raman,Ayush T. Raman,Martin J. Aryee,Martin J. Aryee,Peter van Galen,Peter van Galen,Peter van Galen,Volker Hovestadt,Bradley E. Bernstein,Bradley E. Bernstein +13 more
TL;DR: In this article, an extended representation bisulfite sequencing (XRBS) method was proposed for targeted profiling of DNA methylation, which can expand coverage of regulatory elements and enrich informative CpG dinucleotides in promoters, enhancers and CTCF binding sites.
Journal ArticleDOI
Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer.
Kyla A.L. Collins,Timothy J. Stuhlmiller,Jon S. Zawistowski,Michael P. East,Trang T. Pham,Claire R. Hall,Daniel R. Goulet,Samantha M. Bevill,Steven P. Angus,Sara H. Velarde,Noah Sciaky,Tudor I. Oprea,Lee M. Graves,Gary L. Johnson,Shawn M. Gomez +14 more
TL;DR: Comprehensive MIBs-based capture of kinases provides a unique proteomics-based method for integration of poorly characterized kinases of the understudied kinome into functional subnetworks in breast cancer cells and tumors that is not possible using genomic strategies.