D
David B. Darr
Researcher at University of North Carolina at Chapel Hill
Publications - 55
Citations - 4350
David B. Darr is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 28, co-authored 55 publications receiving 3528 citations.
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Journal ArticleDOI
Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
James S. Duncan,Martin C. Whittle,Kazuhiro Nakamura,Amy N. Abell,Alicia A. Midland,Jon S. Zawistowski,Nancy Lassignal Johnson,Deborah A. Granger,Nicole Vincent Jordan,David B. Darr,Jerry Usary,Pei Fen Kuan,David M. Smalley,Ben Major,Xiaping He,Katherine A. Hoadley,Bing Zhou,Norman E. Sharpless,Charles M. Perou,William Y. Kim,Shawn M. Gomez,Xin Chen,Jian Jin,Stephen V. Frye,H. Shelton Earp,Lee M. Graves,Gary L. Johnson +26 more
TL;DR: The inhibitor-induced RTK profile suggested a kinase inhibitor combination therapy that produced GEMM tumor apoptosis and regression where single agents were ineffective, allowing rational design of combination therapies for cancer.
Journal ArticleDOI
The genome architecture of the collaborative cross mouse genetic reference population
Fuad A. Iraqi,Mustafa Mahajne,Yasser Salaymah,Hani Sandovski,Hanna Tayem,Karin Vered,Lois Balmer,Michael R. Hall,Glynn Manship,Grant Morahan,Ken Pettit,Jeremy Scholten,Kathryn Tweedie,Andrew Wallace,Lakshini Weerasekera,James Cleak,Caroline Durrant,Leo Goodstadt,Richard Mott,Binnaz Yalcin,David L. Aylor,Ralph S. Baric,Timothy A. Bell,Katharine M. Bendt,J. Brennan,Jackie D. Brooks,Ryan J. Buus,James J. Crowley,John D. Calaway,Mark Calaway,Agnieszka Cholka,David B. Darr,John P. Didion,Amy Dorman,Eric T. Everett,Martin T. Ferris,Wendy Foulds Mathes,Chen Ping Fu,Terry J. Gooch,Summer G. Goodson,Lisa E. Gralinski,Stephanie D. Hansen,Mark T. Heise,Jane Hoel,Kunjie Hua,Mayanga C. Kapita,Seunggeun Lee,Alan B. Lenarcic,Eric Yi Liu,Hedi Liu,Leonard McMillan,Terry Magnuson,Kenneth F. Manly,Darla R. Miller,Deborah A. O'Brien,Fanny Odet,Isa Kemal Pakatci,Wenqi Pan,Fernando Pardo-Manuel de Villena,Charles M. Perou,Daniel Pomp,Corey R. Quackenbush,Nashiya N. Robinson,Norman E. Sharpless,Ginger D. Shaw,Jason S. Spence,Patrick F. Sullivan,Wei Sun,Lisa M. Tarantino,William Valdar,Jeremy Wang,Wei Wang,Catherine E. Welsh,Alan C. Whitmore,Tim Wiltshire,Fred A. Wright,Yuying Xie,Zaining Yun,Vasyl Zhabotynsky,Zhaojun Zhang,Fei Zou,Christine L. Powell,Jill Steigerwalt,David W. Threadgill,Elissa J. Chesler,Gary A. Churchill,Daniel M. Gatti,Ron Korstanje,Karen L. Svenson,Francis S. Collins,Nigel P.S. Crawford,Kent W. Hunter,N. Samir,P. Kelada,Bailey C.E. Peck,Karlyne M. Reilly,Urraca Tavarez,Daniel Bottomly,Robert Hitzeman,Shannon K. McWeeney,Jeffrey A. Frelinger,Harsha Krovi,Jason Phillippi,Richard A. Spritz,Lauri D. Aicher,Michael G. Katze,Elizabeth Rosenzweig,Ariel Shusterman,Aysar Nashef,Ervin I. Weiss,Yael Houri-Haddad,Morris Soller,Robert W. Williams,Klaus Schughart,Hyuna Yang,John E. French,Andrew K. Benson,Jaehyoung Kim,Ryan Legge,Soo Jen Low,Fangrui Ma,Inés Martínez,Jens Walter,Karl W. Broman,Benedikt Hallgrímsson,Ophir D. Klein,George M. Weinstock,Wesley C. Warren,Yvana V. Yang,David A. Schwartz +129 more
TL;DR: The Collaborative Cross Consortium reports here on the development of a unique genetic resource population, a multiparental recombinant inbred panel derived from eight laboratory mouse inbred strains, which shows that founder haplotypes are inherited at the expected frequency.
Journal ArticleDOI
Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.
Christin E. Burd,Jessica A. Sorrentino,Kelly S. Clark,David B. Darr,Janakiraman Krishnamurthy,Allison M. Deal,Nabeel Bardeesy,Diego H. Castrillon,David H. Beach,Norman E. Sharpless +9 more
TL;DR: It is suggested that p16(INK4a) activation is a characteristic of all emerging cancers, making the p 16(LUC) allele a sensitive, unbiased reporter of neoplastic transformation.
Journal ArticleDOI
Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling
Ronald L. Chandler,Jeffrey S. Damrauer,Jesse R. Raab,Jonathan C. Schisler,Matthew D. Wilkerson,John P. Didion,Joshua Starmer,Daniel W. Serber,Della Yee,Jessie Xiong,David B. Darr,Fernando Pardo-Manuel de Villena,William Y. Kim,Terry Magnuson +13 more
TL;DR: An epistatic relationship between SWI/SNF chromatin remodeling and PI3K pathway mutations in OCCC is established and it is proposed that ARID1A protects against inflammation-driven tumorigenesis.
Journal ArticleDOI
Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy
Patrick J. Roberts,John E. Bisi,Jay C. Strum,Austin J. Combest,David B. Darr,Jerry Usary,William C. Zamboni,Kwok-Kin Wong,Charles M. Perou,Norman E. Sharpless +9 more
TL;DR: The present data support a possible role for CDK4/6 inhibitors in a majority of patients with advanced cancer and suggest statistically significant protection of platelets in tumor-bearing mice.