S
Samantha N. Cobos
Researcher at City University of New York
Publications - 8
Citations - 100
Samantha N. Cobos is an academic researcher from City University of New York. The author has contributed to research in topics: Histone & Epigenetics. The author has an hindex of 2, co-authored 4 publications receiving 58 citations. Previous affiliations of Samantha N. Cobos include Brooklyn College.
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Journal ArticleDOI
Epigenetics in amyotrophic lateral sclerosis: a role for histone post-translational modifications in neurodegenerative disease.
TL;DR: Both local and global changes in histone modification profiles are associated with ALS drawing attention to potential targets for future diagnostic and treatment approaches.
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The impact of histone post-translational modifications in neurodegenerative diseases.
TL;DR: Recent advances on the association of histone post-translational modifications with ALS, FTD, PD and several ataxias are reviewed.
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Epidrugs in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia: Contextualizing a Role for Histone Kinase Inhibition in Neurodegenerative Disease.
TL;DR: The future of epidrugs against neurodegeneration is expanded and promising novel targets underexploited thus far are discussed: histone kinases.
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Trichostatin A Relieves Growth Suppression and Restores Histone Acetylation at Specific Sites in a FUS ALS/FTD Yeast Model.
Seth A. Bennett,Seth A. Bennett,Samantha N. Cobos,Samantha N. Cobos,Melagras Mirzakandova,Michel Fallah,Elizaveta Son,George Angelakakis,Navin Rana,Muna M Hugais,Mariana P. Torrente,Mariana P. Torrente +11 more
TL;DR: In this article, the authors showed that inhibiting histone deacetylases, via treatment with trichostatin A, suppresses the toxicity associated with FUS overexpression in yeast by preserving the levels of H3K56ac and H3k14ac without affecting the expression or aggregation of FUS.
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Investigation of the Effects and Mechanisms of Anticancer Action of a Ru(II)-Arene Iminophosphorane Compound in Triple Negative Breast Cancer Cells.
TL;DR: Ru-IM (1) as mentioned in this paper is a water-soluble organometallic ruthenium compound, which was shown to be effective in triple negative breast cancer (TNBC) cell lines derived from patients of European and African ancestry.