Epidrugs in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia: Contextualizing a Role for Histone Kinase Inhibition in Neurodegenerative Disease.
TLDR
The future of epidrugs against neurodegeneration is expanded and promising novel targets underexploited thus far are discussed: histone kinases.Abstract:
Breakthroughs in understanding the epigenetic mechanisms involved in neurodegenerative disease have highlighted "epidrugs" as a potential avenue for therapeutic development. Here, we expand on the future of epidrugs against neurodegeneration and discuss promising novel targets underexploited thus far: histone kinases.read more
Citations
More filters
Journal ArticleDOI
Virtual Special Issue: Epigenetics 2022.
Courtney C. Aldrich,Félix Calderón,Stuart J. Conway,Chuan He,Jacob M Hooker,Donna M. Huryn,Craig W. Lindsley,Dennis C. Liotta,Christa E. Müller +8 more
TL;DR: The Altmetric Attention Score as mentioned in this paper is a quantitative measure of the attention that a research article has received online, which is used to measure the importance of an article in the literature.
Journal ArticleDOI
Virtual Special Issue: Epigenetics 2022.
Courtney C. Aldrich,Félix Calderón,Stuart J. Conway,Chuan He,Jacob M Hooker,Donna M. Huryn,Craig W. Lindsley,Dennis C. Liotta,Christa E. Müller +8 more
TL;DR: The Altmetric Attention Score as mentioned in this paper is a quantitative measure of the attention that a research article has received online, and it is calculated using a weighted average of the number of clicks received by the article.
Journal ArticleDOI
Virtual Special Issue: Epigenetics 2022.
Courtney C. Aldrich,Félix Calderón,Stuart J. Conway,Chuan He,Jacob M Hooker,Donna M. Huryn,Craig W. Lindsley,Dennis C. Liotta,Christa E. Müller +8 more
TL;DR: The Altmetric Attention Score as discussed by the authors is a quantitative measure of the attention that a research article has received online, and it is calculated using a weighted average of the number of articles that have been published in the last few days.
Journal ArticleDOI
Virtual Special Issue: Epigenetics 2022.
Courtney C. Aldrich,Félix Calderón,Stuart J. Conway,Chuan He,Jacob M Hooker,Donna M. Huryn,Craig W. Lindsley,Dennis C. Liotta,Christa E. Müller +8 more
TL;DR: The Altmetric Attention Score as mentioned in this paper is a quantitative measure of the attention that a research article has received online, which is used to measure the importance of an article in the literature.
Journal ArticleDOI
Current State and Future Directions in the Therapy of ALS
TL;DR: A review of the current state of ALS therapy, including medication as well as supportive therapy, and discuss the ongoing developments and prospects in the field can be found in this article , which highlights the rationale behind the intense research on biomarkers and genetic testing as a feasible way to improve the classification of ALS patients towards personalized medicine.
References
More filters
Journal ArticleDOI
Regulation of chromatin by histone modifications
TL;DR: The known histone modifications are described, where they are found genomically and discussed and some of their functional consequences are discussed, concentrating mostly on transcription where the majority of characterisation has taken place.
Journal ArticleDOI
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
Silke Hauf,Richard W. Cole,Sabrina LaTerra,Christine Zimmer,Gisela Schnapp,Rainer Walter,Armin Heckel,Jacques van Meel,Conly L. Rieder,Jan-Michael Peters +9 more
TL;DR: The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
Journal ArticleDOI
Role of JNK activation in apoptosis: A double-edged sword
Jing Liu,Anning Lin +1 more
TL;DR: JNK has pro- or antiapoptotic functions, depending on cell type, nature of the death stimulus, duration of its activation and the activity of other signaling pathways, however, recent studies reveal that JNK can suppress apoptosis in IL-3-dependent hematopoietic cells via phosphorylation of the proap optotic Bcl-2 family protein BAD.
Journal ArticleDOI
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface
Julie P.I. Welburn,Mathijs Vleugel,Dan Liu,John R. Yates,Michael A. Lampson,Tatsuo Fukagawa,Iain M. Cheeseman +6 more
TL;DR: In this article, the authors demonstrate that Aurora B kinase phosphorylates three spatially distinct targets within the conserved outer kinetochore KNL1/Mis12 complex/Ndc80 complex (KMN) network.
Journal ArticleDOI
Histone phosphorylation: A chromatin modification involved in diverse nuclear events
TL;DR: The key roles played by this histone mark in DNA repair, transcription and chromatin compaction during cell division and apoptosis are discussed and the intricate crosstalk that occurs between phosphorylation and other histone modifications and allows for sophisticated control over the chromatin remodeling processes are described.