S
Sameh Saber
Researcher at Delta University for Science and Technology
Publications - 82
Citations - 999
Sameh Saber is an academic researcher from Delta University for Science and Technology. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 45 publications receiving 364 citations. Previous affiliations of Sameh Saber include Zagazig University.
Papers
More filters
Journal ArticleDOI
Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NFκB and Nrf-2/HO-1 signaling crosstalk.
TL;DR: The data show that OLM is an Nrf2 activator, NFkB inhibitor and apoptosis inhibitor in an experimental model of ulcerative colitis and shows promise as a potential therapy for the treatment of human inflammatory bowel diseases.
Journal ArticleDOI
Telmisartan ameliorates dextran sodium sulfate-induced colitis in rats by modulating NF-κB signalling in the context of PPARγ agonistic activity
TL;DR: The study revealed that TEL, particularly at 7 mg/kg, alleviated tissue injury and inflammatory signs upon histological analysis and enhanced survival and recovery during DSS-induced colitis, and concluded that PPARγ and CD36 might play a critical role in the pathogenesis of murine colitis and that further investigations on human IBDs are warranted.
Journal ArticleDOI
Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis
TL;DR: By inhibiting NLRP3 inflammasome and its prerequisite NFκB signalling, simultaneous administration of metformin and celastrol appears to have additive benefits in the treatment of HCC compared to cela monotherapy.
Journal ArticleDOI
Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B
TL;DR: It is concluded that RAS inhibition either through inhibiting the ACE or the blockade of AT1R has the same therapeutic benefit and that the tissue affinity of the ACEIs has no impact on its anti-tumor activity.
Journal ArticleDOI
Deferoxamine-loaded transfersomes accelerates healing of pressure ulcers in streptozotocin-induced diabetic rats
TL;DR: In vitro study revealed that the DFO-loaded transfersomal gel has uniform distribution of DFO, applicable pH, and suitable viscosity and found effective in sustaining DFO release and shows promise as a potential therapy for the treatment of human diabetic ulcers.