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Samir Koirala
Researcher at Harvard University
Publications - 16
Citations - 1481
Samir Koirala is an academic researcher from Harvard University. The author has contributed to research in topics: Perisynaptic schwann cells & Synapse. The author has an hindex of 13, co-authored 15 publications receiving 1390 citations. Previous affiliations of Samir Koirala include Boston Children's Hospital & University of Southern California.
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Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.
TL;DR: How presenilin-dependent nuclear signaling by a receptor tyrosine kinase directly regulates gene transcription and cell fate is defined and could be of importance for neural stem cell biology and for understanding the pathogenesis of Alzheimer's disease.
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GPR56 Regulates Pial Basement Membrane Integrity and Cortical Lamination
Shihong Li,Zhaohui Jin,Samir Koirala,Lihong Bu,Lei Xu,Richard O. Hynes,Christopher A. Walsh,Gabriel Corfas,Xianhua Piao +8 more
TL;DR: This study demonstrates that loss of the mouse Gpr56 gene leads to neuronal ectopia in the cerebral cortex, a cobblestone-like cortical malformation, and provides compelling evidence that GPR56 functions in regulating pial BM integrity during cortical development.
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An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
Ofra Benny,Ofer Fainaru,Avner Adini,Flavia Cassiola,Lauren Bazinet,Irit Adini,Elke Pravda,Yaakov Nahmias,Samir Koirala,Gabriel Corfas,Robert J. D'Amato,Judah Folkman +11 more
TL;DR: Lodamin is an oral nontoxic antiangiogenic drug that can be chronically administered for cancer therapy or metastasis prevention and first reaches the liver, making it especially efficient in preventing the development of liver metastasis in mice.
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Glial Cells Maintain Synaptic Structure and Function and Promote Development of the Neuromuscular Junction In Vivo
TL;DR: In tadpoles, repeated in vivo observations revealed that PSC processes lead nerve terminal growth, and in the absence of PSCs, growth and addition of synapses was dramatically reduced, and existing synapses underwent widespread retraction.
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GPR56-Regulated Granule Cell Adhesion Is Essential for Rostral Cerebellar Development
TL;DR: A novel role is established for GPR56 in the adhesion of developing neurons to basal lamina molecules and it is suggested that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis.