Samuel Barnes

TL;DR: The data suggest that BBB breakdown is an early event in the aging human brain that begins in the hippocampus and may contribute to cognitive impairment.

TL;DR: It is found that pericyte degeneration disrupted white-matter microcirculation, resulting in an accumulation of toxic blood-derived fibrin(ogen) deposits and blood-flow reductions, which triggered a loss of myelin, axons and oligodendrocytes, leading towhite-matter functional deficits before neuronal loss occurs.

TL;DR: A technique is presented that semiautomatically identifies CMBs in susceptibility weighted images (SWI) to reduce the processing time and increase the consistency over manual methods, and presents a faster alternative to current manual techniques at the cost of some lost sensitivity.

TL;DR: By combining filtered phase and magnitude information to create a novel and intrinsic source of contrast, susceptibility-weighted imaging (SWI) has shown great promise in clinical angiography and venography and contributed to new insights into traumatic brain injury, the role of calcification in atherosclerosis, and the possible relationship between blood settling and deep venous thrombosis.

TL;DR: To determine optimal parameters for acquisition and processing of dynamic contrast‐enhanced MRI (DCE‐MRI) to detect small changes in near normal low blood–brain barrier (BBB) permeability, a large number of parameters were selected.