Samuel W. Plaska

TL;DR: Findings prove that WES of CYP11B2-guided mutation-negative APAs can help determine rarer genetic causes of sporadic PA, and detect 2 somatic variants in CLCN2 in 2 APAs that were negative for currently known aldosterone-driver mutations.

TL;DR: Overall, these data support the use of targeted amplicon-based RNAseq for comprehensive transcriptomic profiling of archival FFPE adrenal tumor material and indicate that this approach may facilitate important translational research opportunities for the study of these tumors.

TL;DR: In this article, the authors analyzed the transcript expression of type 1 angiotensin II receptors (AGTR1), ACTH receptors (MC2R), and melanocortin 2 receptor accessory protein (MRAP) in APAs with known aldosterone-driver somatic mutations.

TL;DR: In this paper, the authors describe the application of targeted RNAseq to formalin-fixed paraffin-embedded (FFPE) normal adrenal gland specimens and demonstrate the ability to capture FFPE adrenal zone tissue for targeted transcriptomic analyses.

TL;DR: Clemens et al. as mentioned in this paper found that 15% of variance in the proportion of FPMRS clinic visits to procedures was explained by clustering at the physician level and that increasing surgeon age was associated with a higher proportion of clinic visits.